Family Proteaceae
Grevillea
Grevillea robusta
SILKY OAK

Botany
A tree that grows to 30 m or taller. Leaves are alternate, fernlike, pinnate, and dark green. Leaflets are lanceolate, with entire or lobed margins. The flowers are orange.

Distribution
Native to Australia.
Recently introduced to the Philippines.

Constituents and properties
• Study isolated six new 5-alkylresorcinals and eight known compounds.
• Leaves contain rutin.

Uses
Folkloric
No known folkloric medicinal use in the Philippines.
Others
• Flowers are a rich source of nectar.
• Yellow and green dye from the leaves; used for dyeing silk.
source
• Wood is used for joinery, cabinetry and panelling.

Caution !
Contatct dermatitis: A report on a case of severe acute dermatitis venenata due to exposure to sawdust of Grevillea robusta.
Grevillol:
Bracelets made from the wood of Grevellia were shown to be a source of allergic contact dermatitis. The responsible allergen was grevillol, a phenolic with a long side chain resembling the sensitizing uroshiols from poison ivy. source

Studies
Cytoxicity:
Study isolated 6 new 5-alkylresorcinols and 8 known compounds, all of which showed marginal toxicity against MCF-7 and other cell lines.
Leishmanicidal:
One of 75 Myanmar timber extracts examined for leishmanicidal activity. source
Cardiovascular:
Several his-resorcinols were isolated from Grevellia robusta, the most potent, striatol, exhibiting inhibitory activity on the Ca-ATPase system suggesting a potential for cardiovascular activity.


Availability
Recently for introduced.
Ornamental cultivation.

Additional Sources and Suggested Readings
(1)
Cytotoxic 5-Alkylresorcinol Metabolites from the Leaves of Grevillea robusta
J. Nat. Prod., 2007, 70 (2), pp 319–323 / DOI: 10.1021/np0605687
(2)
Dermatitis Due to Grevillea Robusta (Australian Silk Oak)
STANTON B. MAY, M.D. / Arch Dermatol. 1960;82(6):1006.
(3)
Contact dermatitis from Grevillea'Robyn Gordon'
Contact Dermatitis / Volume 15 Issue 3, Pages 126 - 131
(4)
Antibacterial Activity of Selected Australian Native Plant Extracts
(5)
Investigation of plant-derived phenolic compounds as plasma membrane Ca2+-ATPase inhibitors
with potential cardiovascular activity

Drug development research ISSN 0272-4391 CODEN DDREDK / 1999, vol. 46, no 3-4 (165 p.) (2 p.3/4), pp. 235-249

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SOURCES