Family Euphorbiaceae
Sagilala
Codiaeum variegatum

SAN FRANCISCO / CROTON

Other scientific names  Common names
Ixia chinensis Linn. Sagilala (Tag.)
Pardanthus chinensis Ker Croton (Engl.)
  Buenavista (Span.)
  Ave'ave (Samoa)
  Joseph's coat (Engl.)
  San Francisco (Span.)


Botany
Low branching shrub with attractive and variedly shaped and colored foliage. Leaves are thick and leathery, ovate, oblong to linear, with entire margins, lobed or spirally twisted. Young leaves are usually green, yellow or red, later changing to single color or variegation of gold cream, white, red, maroon, purple, black or brown. Flowers are small, long, axillary, usually unisexual racemes.

Distribution
A very popular cultivated ornamental in the Philippines.

Parts utilized
Leaves.

Properties and constituents
• Leaves are considered purgative, sedative, antifungal, antiamoebic, antioxidant, and anticancerous.
• Considered emmenagogue and abortifacient.
• Studies have yielded alkaloids, terpenes, flavonoids.

Study of six clone cultivars of Codiaeum variegatum showed the shoots to be rich in alkaloids (most abundant), cardiac glycosides, saponins, tannins, cardenolides, steroids and phyllates.

Uses
Folkloric
Freeze-dried leaf decoction taken as tea in the Philippines (Gertrudes, 2006).
Decoction of crushed leaves for diarrhea.
Young leaves, with Pandanus macroieacceretia, coconut milk, and root sap of areca catechu used for gonorrhea.
Sap of leaves mixed with coconut milk used for syphylitic lesions.
In Nigeria, root decoction used for gastric ulcers. Leaves, for antibacterial and antiamoebic uses.
In the Kagera and Coast regions, used for the treatment of epilepsy.
In Vanuatu, leaves used for amenorrhea. Chewing of 3 leaves and swallowing the juice used as emmenagogue, to induce abortion or facilitate parturition. source

Studies
Phytochemicals: Phytochemical screening of six clone cultivars of Codiaeum variegatum showed bioactive constituents that included alkaloids, anthraquinones, flavanoids, terpenes, steroid, phenol, saponins, tannins, phlobatannin and cardenolide which suggests their use as antibacterial, antiamoebic and antifungal.
Antiamoebic: In a study of 55 traditional medicinal plants in Cameroon, only the leaves extract of Codiaeum variegatum exhibited clear antiamoebic activity, more pronounced than metronidazole.
Anti-influenza: A screening of seven Euphorbiaceae species showed C variegatum to be one of three with relevant anti-FLUAV activity from an isolated cyanoglucoside.
Anti-convulsant: Study showed methanol extract portected mice against picrotoxin-induced convulsions.

Immunestimulating / Spermatotoxic: Study on 24 male albino rats with feeds supplemented by pulverized dry leaves of C variegatum showed immunostimulating and spermatotoxic effects.
Molluscicidal Activity: Study showed the latex of Codiaeum variegatum had high molluscicidal activity against freshwater snail.

Toxicity !
• Chewing on the bark and roots can cause burning around and in the mouth. Some leaves are reported irritant. Latex have been reported to cause eczema. source

Availability
Cultivated.


Additional Sources and Suggested Readings
(1)
IN VITRO PROPAGATION OF CROTON (CODIAEUM VARIEGATUM) / Pak. J. Bot., 40(1): 99-104, 2008.
(2)
Cultivars of Codiaeum variegatum (L.) Blume (Euphorbiaceae) show variability in phytochemical and cytological characteristics / African Journal of Biotechnology Vol. 6 (20), pp. 2400-2405, 18 October 2007 / http://www.academicjournals.org/AJB / / ISSN 1684–5315 © 2007 Academic Journals
(3)
IN VITRO AMOEBICIDAL ACTIVITY OF SOME MEDICINAL PLANTS OF THE BAMUN REGION (CAMEROON) / Paul F Moundipa et al / Afr. J. Trad. CAM (2005) 2 (2): 113 - 121
(4)
In vitro anti-influenza screening of several Euphorbiaceae species: Structure of a bioactive Cyanoglucoside from Codiaeum variegatum / Phytochemistry Volume 69, Issue 16, November 2008, Pages 2815-2819 / doi:10.1016/j.phytochem.2008.09.003
(5)
A study of the effect of extracts of Codiaeum variegatum (L.) A. Juss on Picrotoxin-induced convulsions in mice / Tanzania Medical Journal Vol. 19 (1) 2004
(6)
Effect of experimental feeding of Codiaeum variegatum leaves on growth, hematology, gonadal, and extra-gonadal sperm reserves of adult albino rats / Shoyinka S V Olumuyiwa et al / Comparative Clinical Pathology • DOI 10.1007/s00580-009-0894-8
(7)
EFFECT OF SUB-LETHAL CONCENTRATIONS OF CODIAEUM VARIEGATUM LATEX ON FRESHWATER TARGET SNAIL LYMNAEA ACUMINATA AND NON-TARGET FISH CHANNA PUNCTATUS / Ram P Yadav and Ajay Singh / Nigerian Journal of Natural Products and Medicine Vol.7 2003: 20-24
(8)
Maternity and medicinal plants in Vanuatu I. The cycle of reproduction / G Bourdya and A Walterb / Journal of Ethnopharmacology, 37 (1992) 179-196 /


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