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Family Menispermaceae
Sansau
Cissampelos pareira Linn.
VELVET LEAF

Xi sheng teng

Scientific names Common names
Cissampelos argentea Kunth Abobo (C. Bis.)
Cissampelos auriculata Miers Bangbañgau (Ilk.)
Cissampelos australis A.St.-Hil. Batang-batang (Tag.)
Cissampelos benthamiana Miers Gulagulamanan (Tag.)
Cissampelos bojeriana Miers Hampapare (Bis.)
Cissampelos caapeba L. Himpapara (Bis.)
Cissampelos cocculus Poir. Kalaad (Ilk.)
Cissampelos convolvulacea Willd. Kalakalamayan (Tag.)
Cissampelos cordifolia Bojer Kalkalaad (Ilk.)
Cissampelos cumingiana Turcz. Kauas (Sub.)
Cissampelos delicatula Miers Kuskusipa (Ilk.)
Cissampelos diffusa Miers Makabo-o (Tag.)
Cissampelos discolor DC. Malaruto (Ibn.)
Cissampelos diversa Miers Samang (Bon.)
Cissampelos elata Miers Sampare (Bis.)
Cissampelos eriantha Miers Sansau (Tag.)
Cissampelos eriocarpa Triana & Planch. Sinchao-sinchauan (Tag.)
Cissampelos glaucescens Triana & Planch. Sinsau-sinsauan (Tag.)
Cissampelos gracilis A.St.-Hil. False pareira (Engl.)
Cissampelos grallatoria Miers Pareira root (Engl.)
Cissampelos guayaquilensis Kunth China jute (Engl.)
Cissampelos haenkeana C.Presl. Ice vine (Engl.)
=Cissampelos heterophylla DC. Indian mallow (Engl.)
Cissampelos hirsutissima C.Presl Velvet leaf (Engl.)
Cissampelos limbata Miers  
Cissampelos littoralis A.St.-Hil.  
Cissampelos longipes Miers  
Cissampelos mauritiana Thouars  
Cissampelos microcarpa DC.  
Cissampelos myriocarpa Triana & Planch  
Cissampelos nephrophylla Bojer  
Cissampelos obtecta Wall.  
Cissampelos orbiculata (L.) DC.  
Cissampelos orinocensis Kunth  
Cissampelos pannosa Turcz.  
Cissampelos pareira Linn.  
Cissampelos pareiroides DC.  
Cissampelos pata Roxb. ex Wight & Am.  
Cissampelos perrieri Diels  
Cissampelos reticulata Borhidi  
Cissampelos salzmannii Turcz.  
Cissampelos subpeltata Thwaites ex Miers  
Cissampelos tamoides Willd. ex DC.  
Cissampelos tetranda Roxb.  
Cissampelos tomentosa DC.  
Cissampelos violifolia Rusby  
Cyclea madagascariensis Baill.  
Cissampelos pareira L. is an accepted name. The Plant List

Other vernacular names
AFRICAN: Kinukadjio.
AYURVEDA: Laghupatha.
BENGALI: Akanadi.
BRAZILIAN: Abutua.
CHINESE: Xi sheng teng.
FRENCH: Feuille de velous, Herbe des sages-femmes, Faux pariera brava.
GUJARATI: Venivel.
KANNADA: Padavali.
HINDI: Padha, Padh, Padhi, Patha, Jaljamini, Laghupatha.
MALAYALAM: Patathali, Kattuvalli.
MALAYSIA: Gasing-gasing, Gegasing, Mempenang.
MARATHIS: Padavela.
NEPALI: Butul poti.
PERUVIAN: Abuta, Burbasco, Sanago.
SPANISH: Butua, Pareira brave.
TAMIL: Vatta tiruppi.
TELUGU: Chiruboddi.

Botany
Sansau is a slender, more or less hairy or nearly smooth, woody twiner. Leaves are oval or heart-shaped, 2 to 7 centimeters long, with a pointed or usually apiculate apex, cordate or subtruncate broad base, usually slightly peltate. Male panicles are slender, 3 to 6 centimeters long, hairy, usually diffuse, with very small, greenish flowers. Female racemes are 2 to 6 centimeters long, with green, kidney-shaped, 1- to 1.5-centimeters long bracts. Fruit is fleshy, nearly spherical, red, 5 to 7 millimeters in diameter, and somewhat hairy. Endocarp is transversely ridged, and tuberculate. Seeds are horse-shoe shaped.

Distribution
- In thickets at low and medium altitudes throughout the Philippines.
- Pantropic.

- Found throughout tropical and subtropical regions
of India, East Africa,and the American tropics.

Constituents
- Main chemical constituents are alkaloids, arachidic acid, bebeerine, berberine, bulbocapnine, cissamine, cissampareine among many others.
- Roots yield pelosin or cissampeline (identical to berberine), and another alkaloid, serperine.

- Plant yields isoquinoline alkaloids; tetrandrine, the most documented of 38 alkaloids.
- A yellow, bitter matter is considered the active principle.
- Phytochemical screening yielded the presence of flavonoids, saponins, triterpenoids, alkaloids, proteins, gums, fatty oils, mucilage, carbohydrates, resins and tannins.
- Phytochemical screening of root extracts yielded terpenoids, alkaloids, tannins, amino acid proteins, and carbohydrates. (17)
- Study isolated one new isoquinoline alkaloid (7), along with six known isoquinoline alkaloids viz. magnoflorine (1), magnocurarine (2), cissamine (3), curine (4), hayatinine (5), and cycleanine (6). (see study below) (37)

Properties
- Roots considered diuretic, emmenagogue, emetic, febrifugal, lithotriptic, pectoral and purgative.
- Leaves are considered cooling, stomachic.
- Tetrandrine considered analgesic, anti-inflammatory and febrifuge.
- Berberine considered antifungal, hypotensive and antimicrobial.
- Studies have shown antioxidant, immunomodulatory, antifertility, antidiarrheal, anticancer, chemopreventive, analgesic, anti-inflammatory, anti-ulcer, diuretic, anti-trypanosomal, hepatoprotective, anthelmintic, antidiabetic, antiviral properties.

Parts used
Whole vine, leaves, roots, seeds, bark.

Uses

Folkloric
- Pounded leaves used for snake bites, abscesses, and wounds.
- Leaves and roots used for treatment of ulcers.
- Leaves used for scabies.
- In India, used as stomachic. Tribal people use the plant to prevent pregnancy.
- Roots used as diuretic.
- Decoction or extract of the root is used for acute and chronic cystitis.
- In Mexico, infusion of roots used for nephritic colic and vesicular calculus.
- Root used as emmenagogue; for treatment of urinary and venereal diseases.
- Used for snake bites and scorpion stings.
- Used as tonic.
- In Reunion and Madagascar, used to dissolve stones.
- In some places in India, commonly used as antifertility agent.
- In South America, called Midwives' herb, with its long history of use for women's ailments.
- In the Amazon, used for menstrual cramps, menorrhagia, pre- and post-natal pains.
- In Guyana, poultice of leaves used topically for pain relief.
- The Creoles in Guyana soak the leaves, bark and roots in rum for use as aphrodisiac.
- In Peru, seeds used for snakebites, fevers, venereal diseases; as diuretic and expectorant. Also, leaf tea used for rheumatism and a wood-bark tea used for irregular heartbeats and excessive menstrual bleeding.
- In India, root paste applied locally in skin disease. Root paste mixed with black pepper (Kali mirch) powder use in treatment of malaria. (44)
Others
- Rope: Bast fibers of the bark are made into rope.
- Fish poison: Roots are used as fish poison.


Studies
Antioxidant / Immunomodulatory:
Study of the alkaloidal fraction of roots of C. pareira showed immunosuppressive and antioxidant activities. The antioxidant activity may be due to the presence of both tetrandrine and berberine. (2)
Gastrointestinal Effects / Antidiarrheal: Study of the ethanolic extract of roots of CP exhibited a dose-dependent inhibition of castor oil induced diarrhea while also significantly and dose-dependently reducing intestinal fluid accumulation and gastrointestinal transit. (3)
Antifertility / Leaves / Roots: Study of the leaf extract in female albino mice showed an antifertility effect, altering the pattern and prolonging the length of the estrous cycle with a significant increase in the duration of diestrus stage and significant reduction of number of litters. Hormone analysis showed altered gonadotropin release (LH, FSH and prolactin) and estradiol secretion. (4)
Chemopreventive / Anti-Gastric Cancer: Study of the hydroalcoholic extract of roots of CP forestomach cancer and carcinogen metabolizing enzymes showed the enhanced GSH level and enzyme activities involved in xenobiotic metabolism and maintenance of antioxidant status of the cells suggest a chemopreventive efficacy of CP against chemotoxicity, including carcinogenicity. (5)
Chemopreventive / Anti-Gastric Cancer: Study on the protective effects of CPE in mice showed a protective effect against induced gastric cancer with reduction of tumor incidence, significant reduction of mean number of tumor and significant reduction of tumor multiplicity.
Antinociceptive / Antiarthritic: Study of aqueous extract of roots exhibited significant resistance against mechanical pain. It also showed significant dose-dependent protective effect against complete Freund's adjuvant induced arthritis. (6)
Anti-Inflammatory: Study data indicate CP roots extract possesses significant anti-inflammatory activity without ulcerogenic activity suggesting a potential as an anti-inflammatory agent for use in inflammatory diseases. (7)
Gastroprotective / Anti-Ulcer: Study isolated a flavonoid, quercetin, from C. pareira, and showed significant antiulcer property against gastric ulcers in different acute models. C. pareira significantly enhanced the defense factors while significantly reducing the ulcer index in ethanol-induced ulcers. (8)
Analgesic / Anti-Inflammatory: Extract study showed significant dose-dependent activity in carrageenin testing, based on interference with prostaglandin synthesis, confirmed by arachidonic acid test. LD50 also showed low toxicity. (9)
Tumor Inhibitors / Cytotoxicity: Study yielded a new alkaloid, cissampareine and four other bisbenzylisoquinoline alkaloids. The alkaloid compounds showed significant and reproducible inhibitory activity against human carcinoma of the nasopharynx carried in cell culture (KB). (10)
Diuretic: In a comparative evaluation of the diuretic potential of the methanolic root extracts of C. pareira, Cyclea peltata and Stephania japonica, all the extracts showed dose-dependent diuretic effects. (C. peltata showed the highest diuretic activity). (13) Study evaluated the diuretic activity of ethanolic extract of leaves in albino rats. Results showed significant increase in urine output along with increase concentration of sodium, potassium and chloride. (13)
Anti-Inflammatory: Study evaluated a methanolic extract of root for anti-inflammatory activity on carrageenan-induced paw edema in male albino rats. Results showed significant anti-inflammatory activity similar to ibuprofen and indomethacin. (15)
Hepatoprotective / Carbon-Tetrachloride: Study of hydroalcoholic extract of roots showed significant dose-dependent hepatoprotective action against CCl4-induced hepatotoxicity. Standard drug was silymarin. (16)
Cissampeloflavone / Anti-Trypanosomal: Study of aerial parts of Cissampelos pareira L. (Menispermaceae), isolated a chalcone-flavone dimer, 2-(4-hydroxy-3-methoxyphenyl)-7-(4-methoxyphenyl)-6-(2- hydroxy-4,6-dimethoxybenzoyl)-furano[3,2-g]benzopyran-4-one--named cissampeloflavone. The compound showed good activity against Trypanosoma cruzi and T. brucei rhodesiense. (18)
Antihyperglycemic: Study of methanolic root extract exhibited dose-dependent antihyperglycemic activity in streptozotocin-induced diabetic rats. (19)
Antioxidant: Study of ethanol root extract yielded a large amount of polyphenols. Results showed compelling antioxidant activity in vitro and against stress induced by gastric carcinogen benzo(a)pyrene in vivo. (20)
Antipyretic: Study evaluated the methanolic extracts of important sources of the Ayurvedic drug Patha viz. roots of Cissampelos pareira var. hirsuta, Cyclea peltata, and Stephania japonica. The methanol extract of Cissampelos pareira var. hirsuta at dose of 200 mg/kbw showed significant antipyretic activity. (21)
PM52 / Cognitive Benefits / Alzheimer's Disease: Study evaluated the protective effect of a combined extract of Cissampelos pareira and Anethum graveolens, against age-related cognitive impairment in animal model of age-related cognitive impairment. All doses of PM52 could attenuate memory impairment and neurodegeneration in the hippocampus, possibly through suppression of AChE and decreased oxidative stress in the hipoccampus. Results suggest a potential as food supplement to protect against age-related cognitive impairment like MCI and Alzheimer's. (22)
Antidiabetic / Leaves: Study evaluated a leaf extract for potential anti-hyperglycemic activity in fructose-alloxan-induced diabetic rats. Results showed significant reduction in serum glucose and percent glycosylated hemoglobin. There was a significantly higher percent ß-cell granulation scores in CLE-treated animals. Enhancement of macrophage phagocytosis suggests a possible role in immuno-modulation. (23) Study evaluated the in vivo hypoglycemic activity of aqueous leaf extracts of C. pareira in while male albino alloxan induced diabetic rats. Results showed hypoglycemic activity with the intraperitoneal dose more effective than oral route. On toxicity study, slight toxicity was noted at 1 g/kbw daily for 28 days. (35)
Antihelmintic: Study evaluated the anthelmintic activity of the whole plant of Cissampelos pareira against earthworm Pheretima posthuma using alcoholic and aqueous extracts in various concentrations. Both extracts showed significant activity with the aqueous extract being more effective. (24)
Cardioprotective / Roots: Study of C. pareira root extract for cardioprotective effect in rats showed attenuation of isoproterenol-induced cardiac dysfunction possibly through amelioration of carlcineurin activity and free radical formation, and by augmentation of enzyme activities. (25)
Toxicological Screening: A 50% aqueous ethanolic extract was found safe in acute and subacute toxicity screening. (27)
Antimicrobial: Study showed Cissampelos pareira has antibacterial activity against four of six tested bacteria. The highest inhibition was against S. aureus 20 mm, S. typhimurium 17 mm. K. pneumoniae 14 mm, and E. coli 9 mm. Phytochemical screening yielded alkaloids, flavonoids, tannins, terpenoids and steroids. (28)
Anticancer / Dalton's Lymphoma Ascites: Study demonstrated C. pareira exhibited significant imputable in vitro cytotoxic and in vivo antitumor activity against Dalton's Lymphomas Ascites (CLA) cells in Swiss mice. Effect was attributable to increasing endogenous mechanisms of antioxidant property. (29)
Anxiolytic / Leaves: Study of a 70% hydroethanolic extract of leaves of Cissampelos pareira showed anxiolytic effect using elevated plus maze test, light dark model, and forced swim test models in rats.       (31)
Antimalarial / Roots: Study of root extracts of Cissampelos pareira and stem extracts of Tinospora cordifolia for antimalarial activity showed significant inhibition of propagation of rodent parasite Plasmodium berghei in vivo. (32)
• Bioactivity Against Mycobacrerium tuberculosis / Antibacterial: Study evaluated C. pareira for anti-tuberculosis activity. Results showed anti-tuberculosis activity with MIC ranging between 50 and 6.25 µg/ml among all fractions. Antibacterial activity was broad spectrum with the methanolic fraction yielding the highest activity of 28 mm in S. aureus. Activity may be attributable to phytochemicals alkaloids, flavonoids, terpenoids, anthraquinones and phenols. (33)
• Potent Antiviral Activity Against All Four Dengue Virus Serotypes: Study showed the alcoholic extract of Cissampelos pareira Linn. (Cipa extract) was a potent inhibitor of all four Dens in cell-based assays, in terms of viral NS1 antigen secretion and viral replication. Reduction assays showed Cipa extract could decrease viral titers by an order of magnitude. There was statistically significant protection against DENV infection in the AG129 mouse model. Preliminary evaluation showed no adverse effects on platelet counts and RBC viability. It also possess the ability to down-regulate the production of TNF-a, a cytokine implicated in severe dengue disease. Furthermore, there was no evidence of toxicity in Wistar rats at doses as high as 2g/kbw for up to 1 week. (34)
• Attenuation of Age-Related Cognitive Impairment: Study evaluated the protective effect and mechanism of PM52, a combined extract of C. pareira and Anethum graveolens, against age-related cognitive impairment in an animal model. Results showed PM52 could attenuated memory impairment and neurodegeneration in the hippocampus. Study suggests the potential for PM52 as a food supplement to protect against age-related cognitive impairments, as in mild cognitive impairment and early phase of Alzheimer's disease. (36)
• Isoquinoline Alkaloids / Cytoxicity: Study isolated one new isoquinoline alkaloid along with six known isoquinoline alkaloids. Chloroform and n-butanol fractions showed cytotoxicity against KB cells. Among the pure compounds, hayatinine (5) was found most active against KB and A549, while cycleanine (6) showed against KB cells. (see constituents above) (37)
• No Antifertility Effect / Roots: Study evaluated a methanolic root extract for antifertility effect on the estrous cycle, implantation and reproductive hormones in female rats. Results showed the CP root had no effect on extending the estrous cycle nor on implantation. Study concludes that the alkaloids, the chief chemical component present in the root, has no role in regulating fertility. (38)
• Antioxidant / α-Glucosidase Inhibitory Activity / Antidiabetic / Leaves: Study evaluated the antioxidant and α-glucosidase inhibitory activity of fresh leaves of Cissampelos pareira. Alcohol and EA extracts showed significant antioxidant properties. In vitro assay for α-glucosidase property showed an IC50 of 98.23 ± 0.47 µg/ml. Study provides evidence for antioxidant and antidiabetic properties of the plant. (39)
• Antidiabetic / Leaves: Study evaluated the antidiabetic action of a hydroalcoholic extract of C. pareira leaves in streptozotocin induced diabetic rats. Results showed antidiabetic activity comparable to the standard drug glibenclamide at a dose of 5 mg/kg. (40)
• Acute Toxicity Study: Acute toxicity study of C. pareira extract was investigated on female wistar rats. According to OECD 2001 guidelines, the extract was found safe up to a dose of 2000 mg/kg. (41)
• Potential Benefit in IBD (Irritable Bowel Disease): Study evaluated a methanolic extract of C. pareira on acetic acid and DSS induced colitis in rats and mice. Results showed CP exerted marked protective effects in acute experimental colitis. The effect may be due to regulations in production and expression of inflammatory mediators. Results suggest a potential use in the treatment of IBD. (42)
• Anti-Inflammatory / Roots: Study investigated methanolic extract of roots of C. pareira for anti-inflammatory activity using Carrageenan induced hind paw edema model. Results showed anti-inflammatory activity that may be attributable to inhibitory interaction of the plant extract with cyclooxygenase-2 and subsequent reduction in prostaglandin production. (43)
• Antidepressant / Leaves: Study evaluated the pharmacologic activity of C. pareira leaves that contain bis benzylisoquinoline alkaloids (BIA), tetrandin, bebriberin, and flavones known for their anxiolytic activity. Study evaluated the antidepressant activity of CP extract using Tail suspension test and Forced swim test and duration of immobility. Results showed significant antidepressant activity compared with standard Imipramine. (45)

Availability
- Wild-crafted.

© Godofredo U. Stuart Jr., M.D.


Updated December 2017 / December 2014


IMAGE SOURCE / Photograph /Menispermaceae : Cissampelos pareira / Infructescence / Copyright © 2012 by P.B. Pelser & J.F. Barcelona (contact: pieter.pelser@canterbury.ac.nz) [ref. DOL46956] / PhytoImages.siu.edu / Click on image to go to source page
OTHER IMAGE SOURCE: / File:Cissampelos pareira Blanco2.432.jpg / Flora de Filipinas / Francisco Manuel Blanco (OSA) / 1877-1883 / Public domain / Modifications made by Carol Spears / Wikimedia Commons
OTHER IMAGE SOURCE: / Illustration / Cissampelos pareira L. [5809-247450-161657] / Indian medicinal plants, vol. 1: t. 42 / PlantIllustrations.org

Additional Sources and Suggested Readings
(1)
ABUTA (Cissampelos pareira) / Raintree / Tropical Plant Database
(2)
Antioxidant and Immunomodulatory Activity of the Alkaloidal Fraction of Cissampelos pareira Linn. / Anand Bafna, Shrihari Mishra / Sci Pharm. 2010; 78: 21–31 doi:10.3797/scipharm.0904-16
(3)
Ethnomedical value of Cissampelos pareira extract in experimentally induced diarrhoea / Amresh Gaddam Dayanand Reddy et al / Acta Pharm. 54 (2004) 27–35
(4)
Antifertility activity of the methanolic leaf extract of Cissampelos pareira in female albino mice / Mausumi Ganguly et al /
Journal of Ethnopharmacology, Volume 111, Issue 3, 22 May 2007, Pages 688-691 / doi:10.1016/j.jep.2007.01.023 |
(5)
Evaluation of Cissampelos pareira Against Gastric Cancer and Enzymes Associated with Carcinogen Metabolism / G Amresh, Chandana Venkateswara Rao, Paras Nath Singh / Pharmaceutical Biology, Volume 45, Issue 8 October 2007 , pages 595 - 603
(6)
Antinociceptive and antiarthritic activity of Cissampelos pareira roots / Amresh G, Singh PN, Rao C / J Ethnopharmacol. 2007 May 22;111(3):531-6. Epub 2006 Dec 28.
(7)
Evaluation of anti-inflammatory activity of Cissampelos pareira root in rats / G Amresh, G D Reddy et al /
Journal of Ethnopharmacology, Vol 110, Issue 3, 4 April 2007, Pages 526-531 / doi:10.1016/j.jep.2006.10.009 |
(8)
Gastroprotective effects of ethanolic extract from Cissampelos pareira in experimental animals / G Amresh, Hussain Zeashan et al / Journal of Natural Medicines, Volume 61, Number 3 / July, 2007 / DOI 10.1007/s11418-007-0141-z
(9)
Prostaglandin mediated anti-inflammatory and analgesic activity of Cissampelos pareira / G Amresh, H Zeashan et al / Acta Pharmaceutica Sciencia 49: 153-160 (2007)
(10)
Tumor inhibitors VI. Cissampareine, new cytotoxic alkaloid from Cissampelos pareira. Cytotoxicity of bisbenzylisoquinoline alkaloids / S Morris Kupchan, A C Patel, Elichi Fujita / Journal of Pharmaceutical Sciences, Volume 54 Issue 4, Pages 580 - 583 / DOI 10.1002/jps.2600540419
(11)
Pharmacognostical and Phytochemical Evaluation of Leaves of Cissampelos pareira / Arti Gupta, Sonia Pandey, D.R Shah, N.R. Seth, J.S. Yadav / DOI: 10.5530/pj.2011.21.4
(12)
Chemomodulatory Influence of Cissampelos pareira (L.) Hirsuta on Gastric Cancer and Antioxidant System in Experimental Animal / G. Amresh, R. Kant, Ch.V. Rao and P.N. Singh / Acta Pharmaceutica Sciencia, 49: 71-83 (2007)
(13)
Studies on diuretic activity of three plants from Menispermaceae family / K K Hullatti, M S Sharada, and I J Kuppasth / Pelagia Research Library, Der Pharmacia Sinica, 2011, 2 (1): 129-134
(14)
Cissampelos pareira / Vernacular names / GLOBinMED
(15)
Anti-inflammatory activity of Methanolic extract of Root of Cissampelos pareira on Carragenin induced rat paw edema / Gourab Saha*, Pankaja Senapati, Narahari Sahu, Dr. Sambit Parida / Pharma Tutor
(16)
In vitro and in vivo hepatoprotective activity of Cissampelos pareira against carbon-tetrachloride induced hepatic damage / S. Surendran, M Bavani Eswaran, M Vijayakumar and Ch V Rao / Indian Journal of Experimental Biology, Vol 49, Dec 2011, pp 939-945
(17)
Phytochemical investigation and pharmacognostic standardization of Cissampelos pareira root / Jhuma Samanta, S Bhattacharya, Rana Rayat / Ancient Sci Life 2012;31:181-4 / DOI: 10.4103/0257-7941.107352
(18)
Cissampeloflavone, a chalcone-flavone dimer from Cissampelos pareira. / Ramirez, I; Carabot, A; Melendez, P; Carmona, J; Jimenez, M; Patel, AV; Crabb, TA; Blunden, G; Cary, PD; Croft, SL; Costa, M / Phytochemistry, 64 (2). pp. 645-647, 2003
(19)
Antihyperglycemic activity of methanolic extract of Cissampelos pareira Linn roots on blood glucose levels of Streptozotocin-Induced Diabetic rats / Kumar, K. Atchut; Satyanarayana, T.; Mathwes, Anjana; Rao, Y. Srinivasa; Kiran, K. Raj / Journal of Pharmacy Research, Oct2011, Vol. 4 Issue 10, p3399
(20)
Antioxidant activity of Cissampelos pareira on benzo(a)pyrene-induced mucosal injury in mice / G Amresh, Chandana Venkateswara Rao, Paras Nath Singh / Nutrition Research, Volume 27, Issue 10 , Pages 625-632, October 2007
(21)
PHCOG MAG.: Research Article / Comparative Antipyretic activity of Patha: An Ayurvedic drug / K.K Hullatti and M. S. Sharada* / Phcog Mag. Vol 3, Issue 11, Jul-Sep, 2007
(22)
Research Article: Evaluation of Safety and Protective Effect of Combined Extract of Cissampelos pareira and Anethum graveolens (PM52) against Age-Related Cognitive Impairment
/ Wipawee Thukham-mee and Jintanaporn Wattanathorn / Evidence-Based Complementary and Alternative Medicine, Volume 2012 / doi:10.1155/2012/674101
(23)
Anti-diabetic properties of Cissampelos pareira Linn: A common medicinal plant of Assam, India
/ Caroline Basumata, Jogen Chandra Kalita /
(24)
ANTHELMINTIC ACTIVITY OF CISSAMPELOS PAREIRA LINN
/ Prabodh Shukla, Padmini Shukla, B. Gopalakrishna / Pranveer Singh Institute of Technology, Kanpur
(25)
Effect of Cissampelos pareira root extract on isoproterenol-induced cardiac dysfunction / Bhulan Kumar Singh, Krishna Kolappa Pillai, Kanchan Kohli, Syed Ehtaishamul Haque / Journal of Natural Medicines, January 2013, Volume 67, Issue 1, pp 51-60
(26)
Cissampelos pareira L. / Synonyms (partial list) / The Plant List
(27)
Toxicological screening of traditional medicine Laghupatha (Cissampelos pareira) in experimental animals.
/ Amresh G, Singh PN, Rao CV. / J Ethnopharmacol. 2008 Mar 28;116(3):454-60. / doi: 10.1016/j.jep.2007.12.008.
(28)
Screening for Antimicrobial Activity of Cissampelos pareira L. Methanol Root Extract / Njeru S. Ngoci*, Musa Ramadhan, Mwaniki S. Ngari and Oduor P. Leonard / European Journal of Medicinal Plants, ISSN: 2231-0894 ,Vol.: 4, Issue.: 1 (January)
(29)
Anticancer activity of cissampelos pareira against dalton's lymphoma ascites bearing mice / B Samuel Thavamani, Molly Mathew, SP Dhanabal / Pharmacocognosy Magazine, 2014, Volume 10, Issue 39, pp 200-206
(30)
STUDY OF DIURETIC ACTIVITY OF ETHONOLIC EXTRACT OF LEAVES OF CISSAMPELOS PAREIRA IN RATS / SURESH BABU SAYANA, CHRISTINA, TAMBI MEDABALA, PRAVEEN S PATIL / Asian J Pharm Clin Res, Vol 7, Issue 4, 2014, 157-159
(31)
Effect of Cissampelos Pareira Leaves on Anxiety-like Behavior in Experimental Animals / Priyanka Thakur, Avtar Chand Rana / J Tradit Complement Med, 2013;3:188-93. / DOI: 10.4103/2225-4110.114902
(32)
Antimalarial effect of Tinospora cordifolia (Willd.) Hook.f. & Thoms and Cissampelos pareira L. on Plasmodium berghei / Vikram Singh and H. S. Banyal* / CURRENT SCIENCE, VOL. 101, NO. 10, 25 NOVEMBER 2011
(33)
Bioactivity of Cissampelos pareira medicinal plant against Mycobacterium tuberculosis
/ Sospeter Ngoci Njeru, Meshack A. Obonyo, Samwel O. Nyambati, Silas M. Ngari / Journal of Pharmacognosy and Phytochemistry 2015; 3(6): pp 167-173
(34)
Cissampelos pareira Linn: Natural Source of Potent Antiviral Activity against All Four Dengue Virus Serotypes / Ruchi Sood, Rajendra Raut, Poornima Tyagi, Pawan Kumar Pareek et al / PLoS Negl Trop Dis, Dec 2015; 9(12): e0004255 / doi:  10.1371/journal.pntd.0004255
(35)
In Vivo Antidiabetic Activity and Safety In Rats of Cissampelos pareira Traditionally Used In The Management of Diabetes Mellitus In Embu County, Kenya  / Piero NM, Eliud NNM, Susan KN, George OO, Murugi NJ et al.  /  Drug Metab Toxicol 6:184. / doi: 10.4172/2157-7609.1000184
(36)
Evaluation of Safety and Protective Effect of Combined Extract of Cissampelos pareira and Anethum graveolens(PM52) against Age-Related Cognitive Impairment / Wipawee Thukham-mee and Jintanaporn Wattanathorn / Evidence-Based Complementary and Alternative Medicine, Vol 2012 (2012) /
http://dx.doi.org/10.1155/2012/674101
(37)
Bioactive isoquinoline alkaloids from Cissampelos pareira / Manju Bala, shiv Kumar, Kuunal Pratap, Praveen Kumar Verma, Yogendra Padwad and Bikram Singh / Natural Product Research / https://doi.org/10.1080/14786419.2017.1402319
(38)
Evaluation of Cissampelos pareira root for antifertility activity / Jhuma Samanta*, Dr. Snehendu Bhattacharya, Dr.Avtar Chand Rana / Journal of Pharmacy Research 2015,9(2),134-138
(39)
Antioxidant and enzyme inhibitory activities of Cissampelos pareira L. leaf extracts / Mir Zahoor Gul, Sambamurthy Chandrasekaran, Mohd Yasin Bhat, Radheshyam Maurya, Insaf Ahmed Qureshi and Irfan Ahmad Ghazi / Annals of Phytomedicine 5(1): 91-98, 2016
(40)
ANTIDIABETIC ACTIVITY OF HYDRO-ALCOHOLIC EXTRACT OF CISSAMPELOS PAREIRA LINN. LEAVES IN STREPTOZOTOCIN INDUCED DIABETIC RATS / Vishwanath Jannu*, Sai Vishal D, Ranjith Babu V, Harisha B, Ravi Chandra Sekhara Reddy D. / International Journal Of Pharmacy&Technology, Vol 3, Issue 4; Dec 2011
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ACUTE TOXICITY STUDIES OF METHANOLIC BARK EXTRACT OF FICUS RACEMOSAAND ROOT EXTRACT OF CISSAMPELOS PAREIRA / CHOUDHURY PRADEEP KUMAR* AND JADHAV SACHIN / International Journal of Pharma and Bio Sciences, April 2913; 4(2): 1050-1053
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Effect of methanolic extract of Cissampelos pareira on Acetic acid and Dextran Sodium Sulphate (DSS) induced inflammatory bowel disease (IBD) in albino rats and mice
/ Tanvi Desai, Supriya Kumar Das / International Journal of Pharmacological Research, Vol 7, No 10 (2017)
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ANTI-INFLAMMATORY ACTIVITY OF METHANOLIC EXTRACT OF BARK OF FICUS RACEMOSA L. AND ROOT OF CISSAMPELOS PAREIRA L. VAR. HIRSUTA (DC) FORMAN / Choudhury Pradeep Kumar*, Dinda Subas Chandra and Dash Santosh Kumar / INTERNATIONAL JOURNAL OF RESEARCH IN PHARMACY AND CHEMISTRY (2012), 2(4)
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Folk medicinal uses of plant roots from Meerut district, Uttar Pradesh / Amit Tomar / Indian Journal of Traditional Knowledge Vol. 8(2), April 2009, pp. 298-301
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Antidepressant activity of “Cissampelos pareria” extract in mice / P. Venkata Ravikanth, Rama Devi B, Ganji Naveen, K.V.Ramanamurhty / Innovations in Pharmaceuticals and Pharmacotherapy, Vol 3(4) (2016)



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