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Family Buxaceae

Boxwood
Buxus sempervirens L.
BOX

Scientific names Common names
Buxus sempervirens L. Box (Engl.)
Buxus myrtiflolia Lam. Boxwood (Engl.)
  Common Box (Engl.)
  Common Boxwood (Engl.)


Botany
The plant is a woody evergreen shrub, densely branching with thick masses of tiny, green leaves.

Distribution
Recently introduced.
Used as a border plant.
Popular indoor plant, especially for bonsai.

Properties and constituents
• Contains the alkaloid buxine which causes nausea, vomiting and diarrhea. (See Toxicity below)
• Cycloprotobuxine, another alkaloid present in small amount, is being investigated as an anticancer agent.

Uses
Folkloric
• No reported folkloric medicinal use in the Philippines.
• In Tunisia, considered antineoplastic.
• In Italy, employed as antimalarial.
Superstition
• Believed to prevent witches from entering households. Because of its compactness and smallness of leaves, witches, with their penchant for counting leaves and twigs of trees, are stymied trying the count and recount the number of leaves.

Studies
Phytochemials / Steroidal Alkaloids: Phytochemical investigation of roots of B sempervirens isolated seven new steroidal alkaloids.
Butyrylcholinesterase Activity: Chloroform extracts from the plant species of eight families were screened for their anticholinesterase activity on AChE and BChE enzymes. Three extracts, including Buxus sempervirens, were the most active against butyrylcholinesterase enzymes.
Analgesic Activity: In a study of extracts of B sempervirens for analgesic activity, the aerial parts showed varying degrees of analgesic activitry while the roots showed highly significant analgesic effect in a dose-dependent manner.

Toxicity
Livestock: Anecdotal reports of poisoning to farm animals. Accidental grazing may cause respiratory failure and death.
Buxine: Buxine, the principal alkaloid, can cause respiratory paralysis in humans and livestock.

Availability
Wild-crafted.


Additional Sources and Suggested Readings
(1)
PHYTOCHEMICAL AND STRUCTURAL STUDIES ON THE CHEMICAL CONSTITUENTS OF BUXUS SEMPERVIRENS AND B. PAPILLOSA / Samina Naz / Thesis

(2)
Acetylcholinesterase and butyrylcholinesterase inhibitory activity of some Turkish medicinal plants / Orhan I et al / Journal of Ethnopharmacology, Volume 91, Issue 1, March 2004, Pages 57-60 / doi:10.1016/j.jep.2003.11.016 |
(3)
SCREENING OF SOME TURKISH MEDICINAL PLANTS FOR THEIR ANALGESIC ACTIVITY / Fayyaz Ahmad et al / Pakistan Journal of Pharmaceutical Sciences, 6(2); 29-36, July 1993
(4)
Comparative analysis of medicinal plants used in traditional medicine in Italy and Tunisia / Maria Lucia Leoporatti and Kamel Ghedira / Journal of Ethnobiology and Ethnomedicine 2009, 5:31doi:10.1186/1746-4269-5-31


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