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Family Sterculiaceae / Malvaceae
Kakaw
Cacao
Theobroma cacao
CHOCOLATE TREE

Ke ke shu

Scientific names Common names
Theobroma cacao Kakaw (Tag.)
  Cacao (Span.)
  Ke ke shu (Chin.)
  Chocolate tree (Engl.)


Gen info
Chocolate comes from the fruit of the kakaw tree. Kakaw's scientific name "Theobroma" means "food for the gods." In pre-Colmbian times, its bean was a major currency and great trading value.

Botany
· Small tree, growing to 3-5 meters.
· Leaves are alternate, entire, oblong-ovate to oblong, 15-40 cm long, 5-20 cm wide, with pointed tip and rounded base.
· Flowers, solitary or fascicled to trunk and branches; yellowish or nearly white.
· Fruit is oblong, 10-15 cm longs; wrinkled; yellow or purplish.
· Seeds, numerous; embedded in whitish pulp.



Distribution
Widely cultivated for its seeds; nowhere spontaneous.

Insert
Leaves and young fruit bud.

Constituents
· Seeds contain fixed oil, 40-56 %; theobromine; glucose, saccharose; vitamin A, 825-1400 I.U. per 100 gm.; cellulose, 2.8-5.4%; water, 5-7%; ash, 3-5%; starch, 5% and a glucoside, cacarine.
· The mesocarp and seed contain theobromine and caffeine.
· The wall and pulp of the fruit contain arabinose and galactose.
· The flesh contain enzymes: protease, invertase, raffinase, cesease and oxydase.
• Cacao is high in magnesium.
• High in antioxidants, approximately 40 times higher than blueberries.
• Possibly contains MAO inhibitors with effects on serotonin and neurotransmitters.
• Contains PEA (phenylethylamine) and anandamine.

Parts utilized
· Seed, roots.

Uses
Folkloric
· Eczema, dry skin: Roast 10-12 seeds and pound ; apply to affected areas as poultice after a warm compress.
· Root decoction used as emmenagogue (promotes or stimulates menstrual flow) and ecbolic (promotes labor by stimulating uterine contractions.
Others
· Cocoa butter (oil of theobroma) is an excellent emollient for use to prevent chapped lips and hands.
· Food: Cultivated for use in the manufacture of cacao, chocolate, cacao butter, chocolate food, drink or fruit.
· Cacao butter used in the manufacture of confections, toilet articles and cosmetics; in pharmacy, used for pill coating and suppository preparation.


Studies
Hypoglycemic:
Hypoglycaemic Properties of Malaysian Cocoa (Theobroma Cacao) Polyphenols Extract: Study showed that Malaysian cocoa polyphenol extract has a potential of being an insulin-mimetic agent. Further studies are suggested to elucidate on the underlyiing mechanisms for its glucose reduction and insulin mimicking activities.
Anti-Ulcer: Effects of polyphenol substances derived from Theobroma cacao on gastric mucosal lesion induced by ethanol: Study suugests that the antiulcer mechanism of the polyphenols was from radical scavenging and modulation of leukocyte function.
Immune Activity: Effect of Theobroma cacao flavonoids on immune activation of a lymphoid cell line: Extract down-modulated T lymphocyte activiation and the acquired immune response which could be important in autoimmune or chronic inflammatory disease.
Flavonoids / Nitric Oxide / Endothelial Function: (1) Study indicate flavanol-rich foods provide extraordinary health benefits. In populations that no longer consume large quantities of such foods, the risk of cardiac and cancer deaths have significantly increased. (2) Epicatechin, one of the bioactive nutrients in cocoa can promote blood vessel relaxation and the cardio-benefits might not be antioxidant dependent. (3) Studies have suggested the antioxidants and flavonoids in dark chocolate with benefits of lowering effects on blood pressure and LDL cholesterol levels.
Human Platelet Reactivity Modulation: Study sought to evaluate whether a 28-day supplementation with cocoa flavanols and related procyanidin oligomers would modulate human platelet reactivity and primary hemostasis and reduce oxidative markers in vivo. Results showed significant increase in plasma epicatechin and catechin concentrations and significantly decreased platelet function.
Antioxidative Polyphenols: Study isolated clovamide, deoxyclovamide, quercetin and its glucoside. In the bulk oil system, clovamide had the strongest antioxidative activity. Results suggest that chocolate is stable against oxidative deterioration due to the presence of these polyphenolic compounds.
Inhibition of NO Release / Cytokine Secretion Inhibition: Study shows that cocoa flavonoids not only inhibit NO release from macrophages but also down-regulate inflammatory cytokines and chemokines.
Antioxidative Polyphenols: Study shows that cocoa inhibits drug-triggered liver cytotoxicity and prevents apoptosis by inducing autophagy. Results suggest that cocoa can be added to the list of natural chemopreventive agents with a potential for hepatopathy prevention and therapy.

Availability
Wildcrafted.

Last Update April 2010

Additional Sources and Suggested Readings
(1)
Medicinal value of chocolate explored by scientists / Mongabay
(2)
Hypoglycaemic Properties of Malaysian Cocoa (Theobroma Cacao) Polyphenols-Rich Extract / Ruzaidi, A., Abbe Maleyki et al / International Food Research Journal 15(3), (2008)
(3)
Effects of polyphenol substances derived from Theobroma cacao on gastric mucosal lesion induced by ethanol / OSAKABE N., SANBONGI C et al / Bioscience, biotechnology, and biochemistry / 1998, vol. 62, no8, pp. 1535-153
(4)
Pentameric Procyanidins Isolated from Theobroma cacao Seeds Selectively Downregulate ErbB2 in Human Aortic Endothelial Cells / Thomas P. Kenny et al / Experimental Biology and Medicine 229:255-263 (2004)
(5)

Effect of Theobroma cacao flavonoids on immune activation of a lymphoid cell line
(6)
Dietary flavanols and procyanidin oligomers from cocoa (Theobroma cacao) inhibit platelet function / Karen J Murphy, Andriana K Chronopoulos et al / American Journal of Clinical Nutrition, Vol. 77, No. 6, 1466-1473, June 2003
(7)
Antioxidative Polyphenols Isolated from Theobroma cacao / Chiaki Sanbongi et al / J. Agric. Food Chem., 1998, 46 (2), pp 454–457 / DOI: 10.1021/jf970575o
(8)
Flavonoids from Theobroma cacao Down-Regulate Inflammatory Mediators / Emma Ramiro et al / J. Agric. Food Chem., 2005, 53 (22), pp 8506–8511 / DOI: 10.1021/jf0511042
(9)
Protective Activity of Theobroma cacao L. Phenolic Extract on AML12 and MLP29 Liver Cells by Preventing Apoptosis and Inducing Autophagy / Marco Arlorio et al / J. Agric. Food Chem., 2009, 57 (22), pp 10612–10618 / DOI: 10.1021/jf902419t


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