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Family Fabaceae
Kanya pistula
Cassia fistula
PUDDING PIPE TREE

La chang shu

Scientific names Common names
Cathartocarpus fistula  Bistula (C. Bis.) 
Cassia fistula Linn. Caña fistula (Span.) 
  Fistula (C. Bis., Tag.)
  Ibabau (Bis.)
  India laburnum (Engl.)
  Kaña-pestula (Ibn.)
  Kaña-pistula (Tag.)
  Kanya pistula (Tag.)
  Lapad-lapad (Tagb.)
  Lombayong (Bis.)
  Golden shower tree (Engl.)
  Indian laburnum (Engl.)
  Pudding pipe tree (Engl.) 
  Purging cassia (Engl.)
  La chang shu (Chin.)
   


Botany
Moderate-sized, erect deciduous tree. Leaves are pinnate, smooth, 30-40 cm long. Leaflets are ovate, 8-16, about 10 cm long. Flowers are fragrant and bright yellow; borne in long, lax racemes, 30-50 cm long. Pod is cylindric, 30-60 cm long, about 2.5 cm thick, dark brown, pendulous, smooth and shiny. Seeds are numerous, embedded in black, sweet pulp.

Distribution
Found in northern Luzon to Mindanao. Cuultivated as an ornamental flowering tree.

Properties
• Considered antitumor, antioxidant, hypoglycemic, hepatoprotective, antibacterial, hypocholesterolemic and antidiabetic.

Constituents
• Tannin; saccharose, 53-66%; invert sugar; citric acid; coloring matter; pectin; anthraquinone.
• No alkaloid principle.

• Flower and leaf essential oil study yielded 44 compounds. The main components of the flower oil were (E)-nerolidol (38%) and 2-hexadecanone (17%), while the leaf oil consisted mainly of phytol (16.1%).

Parts used and preparation
Leaves, roots and pods.

Uses
Folkloric
Ringworn and other fungal skin infections: Grind leaves into a paste and rub on affected parts.
Laxative: Eat pulp of ripe fruit (4-10 segments). Powdered leaves are also laxative.
Roots are given as a tonic and febrifuge; also, a strong purgative.
Flowers are demulcent and laxative.
In Rhodesia, used for malaria, blackwater fever, blood poisoning, anthrax and dysentery.
In Hindu medicine, pulp is used as cathartic.
Folk remedy for burns, cancer, constipation, convulsion, delirium.
Ayurvedic medicine considers thye seed antibilious and caminative; the root used for adenopathy, leprosy, syphilis, skin diseases; the fruit for abdominal pain, constipation, fever, heart disease, and leprosy.
Yunani use the leaves for inflammation; the flowers as purgative, fruit as antiinflammatory, antipyretic, abortifacient.
In Rhodesia, pulp used for anthrax, food poisoning, blackwater fever, dysentery and malaria.
In the Gold Coast, pulp used as purgative.
In the Far East, uncooked pulp of pods used for constipation.
In Thai traditional medicine, long used as a laxative drug.
Others
Planted as an ornamental tree.
In Mexico, used a firewood source.
Hard reddish wood used for cabinetry, posts, implements, etc.


Studies
Immuno-Modulatory:
MODULATION OF HUMORAL IMMUNITY BY CASSIA FISTULA AND AMOXY-CASSIA: Study of the water extract of fruit of CF and its synergistic antimicrobial combination with amoxicillin showed stimulation of the immune system.
Wound healing:
Wound Healing Potential of Cassia fistula on Infected Albino Rat Model: C fistula treated rats showed better wound closure and improved tisue regeneration . Study provides scientific rationale for the traditional use in wound treatments.

Hepatoprotective
:
(1) Study showed the aqueous extract of the fruit pulp of CF possesses significant hepatoprotective activity. (2) Study concludes that herb is a potential antioxidant and attenuates the hepatotoxic effect of CCl4 by acting as an in vivo antioxidant, inhibiting the initiaition and promotionn of lipid peroxidation.
Laxative:
(1) TOXICITY POTENTIALS OF CASSIA FISTULA FRUITS AS LAXATIVE WITH REFERENCE TO SENNA: Study suggests that C fistula pods can be used for laxative activity with its considerable bioactivity and very low toxicity potential in animal studies. (2) Decoction extract of leaves containing anthraquinone glycosides which may be used as a alternative source of raw material for various laxative preparations.

Pharmacognosy:
Qualitative chemical tests of the ethanol extract revealed the presence of tannins, flavonoids, steroids, glycosides and carbohydrates.
Antitussive:
C. fistula extract inhibition of cough induced by sulfur dioxide gas in mice, exhibiting significant antitussive activity comparable to codeine sulfate, a prototype antitussive agent.
Anti-inflammatory / Antioxidant:
C. fistula bark extracts showed dose-dependent protective effect against lipid peroxidation and free radical generation and significant anti-inflammatory effect in both acute and chronic models.
Antibacterial:
(1) A study showed antibacterial activity of the extract of C. fistula against S. aureus. (2) Study showed the alcoholic extract of leaves of C. fistula showed antimicrobial activity against S aureus, P aeruginosa, E coli and Group A strep.
Antimalarial / Larvicidal / Ovicidal:
Study showed the leaf extract of C. fistula is promising as a larvicidal and ovidal agent against C. quinquefasciatus and S. stephensi.
Antifungal:
Study of crude methanol extracts from the leaves of C alata, C fistula and C tora showed activity against M gypseum conidial germination. C alata was the most effective against T rubrum and M gypseum, while C fistula was the most potent inhibitor of P marneffei.
Hypoglycemic / Hypocholeterolemic:
Study on stretozotocin (STZ)-induced diabetes in rats showed hypoglycemic effects comparable to glibenclamide. Antioxidant and polyphenol content present in the extracts might contribute to the antihyperglycemiic and antilipidemic properties. Results suggest that C fistula barks would be effective in the treatment of diabetes and management of coronary artery disease.


Availability
Wild-crafted.


Last Update May 2010

Photos © Godofredo Stuart / StuartXchange

Additional Sources and Suggested Readings
(1)
MODULATION OF HUMORAL IMMUNITY BY CASSIA FISTULA AND AMOXY-CASSIA / NAFISA HASSAN ALI et al / Pak. J. Pharm. Sci., Vo.21, No.1, January 2008, pp.21-23
(2)
Wound Healing Potential of Cassia fistula on Infected Albino Rat Model / Journal of Surgical Research, Volume 131, Issue 2, Pages 283-289 / M. Senthil Kumar, R. Sripriya, H. Vijaya Raghavan, P. Sehgal
(3)
Hepatoprotective Activity Of Aqueous Extract Of Fruit Pulp Of Cassia Fistula (AFCF) Against Carbon Tetrachloride (CCL4) Induced Liver Damage In Albino Rats. / DAS S, SARMA G, BARMAN S / Journal of Clinical and Diagnostic Research
(4)
TOXICITY POTENTIALS OF CASSIA FISTULA FRUITS AS LAXATIVE WITH REFERENCE TO SENNA

(5)
Cassia fistula L. / James A. Duke. 1983. Handbook of Energy Crops. unpublished.
(6)
Pharmacognostical studies on the bark of Cassia fistula Linn. / Pharmacognosy Journal / Vol 1 Issue 1 . June 2009
(7)
Studies on antitussive activity of Cassia fistula (Leguminosae) leaf extract / BHAKTA T; MUKHERJEE P. K et al / Pharmaceutical biology / 1998, vol. 36, no2, pp. 140-143
(8)
ANTI-INFLAMMATORY AND ANTIOXIDANT ACTIVITIES OF CASSIA FISTULA LINN BARK EXTRACTS / Research Paper / Raju Ilavarasan, Moni Mallika and Subramanian Venkataraman / Afr. J. Trad. CAM (2005) 2 (1): 70 - 85

(9)
Hepatoprotective Activity of Cassia fistula Linn. Bark Extracts against Carbon Tetra Chloride Induced Liver Toxicity in Rats / G. Parthasarathy & V. Prasanth
(10)
ANTIBACTERIAL EFFECT OF CASSIA FISTULA EXTRACT ON PATHOGENIC BACTERIA OF VETERINARY IMPORTANCE / T Ranjith Vimalraj et al / Tamilnadu J. Veterinary & Animal Sciences 5 (3) 109-113, May-June 2009
(11)
THE POTENTIAL OF AQUEOUS AND ISOLATED FRACTION FROM LEAVES OF CASSIA FISTULA LINN AS ANTIBACTERIAL AGENT / Deepa T Vasudevan et al / Int. J. Chem. Sci.: 7(4), 2009, 2363-2367
(12)
Determination of Anthraquinone Glycoside Content in C. fistula Leaf Extracts for an Alternative source of Laxative Drug / Aurapa Sakulpanich and Wandee Gritsanapan / International Journal of Biomedical and Pharmaceutical Sciences / 2009
(13)
Larvicidal and ovicidal activity of Cassia fistula Linn. leaf extract against filarial and malarial vector mosquitoes / M Govindarajan et al / Parasitology Research, Volume 102, Number 2 / January, 2008 / DOI 10.1007/s00436-007-0761-y
(14)
Antifungal activity from leaf extracts of Cassia alata L., Cassia fistula L. and Cassia tora L. / Phongpaichit S et al / Songklanakarin J. Sci. Technol., 2004, 26(5) : 741-748
(15)
Essential Oil from the Flowers and Leaves of Cassia fistula L. / Tzakou O et al / Journal of Essential Oil Research: JEOR, Jul/Aug 2007
(16)
Effect of Hexane Extract of Cassia fistula Barks on Blood Glucose and Lipid Profile in Streptozotocin Diabetic Rats / A Nirmala et al / International Journal of Pharmacology, 2008 | Vol 4 | Issue: 4 | Pg 292-296 /DOI: 10.3923/ijp.2008.292.296


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