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Family Asclepiadaceae
Calotropis gigantea (Linn.) Dryand.

Scientific names Common names
Asclepias gigantea L. Kapal-kapal (Tag.)
Calotropis gigantea (L.) Dryand. Bowstring hemp (Engl.)
Calotropis gigantea (L.) R.Br. ex Schult. Crown flower (Engl.)
Madorius giganteus (L.) Kuntze Crownplant (Engl.)
Periploca cochinchinensis Lour. Giant milkweed (Engl.)
Streptocaulon cochinchinensis (Lour.) G.Don Gigantic swallow wort (Engl.)
  Giant rubber bush (Engl.)
  King's crown (Engl.)
  Swallow wort (Engl.)
Calotropis gigantea (L.) Dryand. is an accepted name The Plant List

Other vernacular names
FRENCH: Faux arbre de soie, Mercure vegetal.
GUJARATI: Aakando.
HINDI: Safed aak, Aak, Alarkh, Madar, Sveta Arka, Bara Akand.
INDONESIA: Bidhuri, Sidaguri, Widuri.
LAOS: Kok may, Dok kap, Dok hak.
MALAYSIA: Remiga, Rembiga, Kemengu.
TAMIL: Erukku.
TELUGU: Jilledi puvvu.
THAI: Po thuean, Paan thuean, Rak.
VIETNAMESE: B[oot]ng b[oot]ng, I[as] hen, Nam t[ot] b[at].

Kapal-kapal is a medium-sized shrub growing to a height of 2 to 4 meters, the young parts covered with appressed white hairs. Bark is pale. Leaves are obovate or oblong, 10 to 20 centimeters long, 3 to 8 centimeters wide, cottony beneath, pointed at the tip, heart-shaped at the base. Flowers have a faint odor, not unpleasant, downy on the outside, arranged in axillary or subterminal, simple or compound, inflorescences. Corolla is 1.5 to 2.5 centimeters across, usually white, sometimes dull-purple or purplish-lilac; the lobes are ovate-lanceolate, and spreading. Fruit is a follicle, recurved, 7.5 to 10 centimeters long. Seeds are ovate, 5 to 6 millimeters long, with a bright, silky-white coma.

- Cultivated for its flowers, about dwellings in Manila and other large towns in the Philippines.
- Recent Introduction from tropical Asia.
- Now pantropic.
now pantropic in cultivation.

- Widely distributed in South China, India, Sri Lanka, Singapore, Malay Islands.

- Active principle appears to be a yellow, bitter resin.
- Root bark contains two substances closely resembling alban and fluavil found in gutta-percha.
- Leaves yield amyrin, amyrin acetate, ß-sitosterol, urosolic acid, cardenolides, calotropin, calotropagenin.
- Early studies of latex yielded an amorphous, bitter principle, calotropin, identical to mundarin.
- Latex contains cardiac glycosides, calotopin, uscharin, calotoxin, calactin and uscharidin; gigantin. Also contains the protease calotropin DI and DII and calotropin FI and FII.

- Ethanolic extract of latex yielded flavonoids, alkaloids, triterpenoids, steroids, saponins, phenols, and glycosides. (see study below) (23)
- Leaves yielded steroids, triterpenoids, glycosides, flavonoids, carbohydrates, and proteins. (see study below)
- Chemical analysis of bark and seed fibers show the main components as holocellulose 76 and 69%, cellulose 57 and 49%, lignin 18 and 23%, and alkali soluble substances 17 and 15%, respectively. (see study below) (38)

- Root bark considered emetic, used as substitute for ipecac.
- Latex is considered bitter, heating, purgative, caustic, acrid, expectorant, depilatory, anthelmintic.
- The latex calotropin, gigantin and uscharin have digitalis-like action on the heart.
- Latex used to induce abortion and infanticide.
- Flowers are considered digestive, stomachic, tonic.
- Studies have suggest analgesic, antimicrobial, antioxidant, antidiarrheal, anti-pyretic, antivenom, cytotoxic, insecticidal, hepatoprotective, wound healing properties.

Parts used
Root, root-bark, leaves and flowers.


- In Java, the central part of the flower used to make sweetmeat.
- Inner part of the flower used for flavoring.
- Bark in small doses, dried and powdered, used as alterative and tonic; in larger doses, an emetic.
- Root-bark reported to promote secretions and used for skin diseases, enlargement of the abdominal viscera, intestinal worms, coughs, ascites, anasarca.
- In India, pulverized root made into ointment, used in the treatment of old ulcers.
- Root bark and inspissated juiced used for leprosy, syphilis, cachexia, idiopathic ulcerations, dysentery, diarrhea, and chronic rheumatism.
- Leaves, warmed and moistened with oil, used as dry fomentation for abdominal pains; also, as rubifacient.
- In India, the acrid milky juice from bruised leaves and stems used for skin affections and as depilatory.
- Fresh or dried juice from the root-bark taken internally as alterative or purgative.
- Juice taken internally or locally as abortifacient. A stick smeared with the juice is pushed into the os uteri and left there until uterine contractions are induced.
- For toothaches, milky juice mixed with salt used for toothache; or juiced cotton inserted in the decayed tooth.
- Juice of young buds used for earache.
- Milky juice used for ringworm of the scalp, sinus problems and anal fistula; also used for pile, and mixed with honey for aphthae of the mouth.
- Flowers used for coughs, asthma, catarrh, and loss of appetite.
- In Ayurveda, used for the treatment of diabetes, bronchial asthma, rheumatoid arthritis, and nervous disorders.
- In Bangladesh, leaves used for treatment of diabetes and pain.
- Ornamental: Flowers are strung into rosaries.
- Fiber: Fiber from inner bark once used in the manufacture of cloth for the nobility. The durable fiber commercially known for bowstrings. Stems yield a durable fiber for products for underwater use: nets, halters, lines, ropes and for making sewing threads.
- Seed hair said to have been used in making thread in Borneo.
- Gunpowder charcoal made from young branches.
- Floss of seeds used for stuffing mattresses.
- Salted acrid milky juice used to remove hair from hides.
- Root makes a good tooth cleanser.
- Root utilized in making charcoal and gunpowder.
- Infanticide: As poison, the juice, forced down the throat of infants, was a reported method of infanticide employed by castes, with the purpose of putting the girl babies to death.

Study of the hydroalcoholic extract of aerial parts of C gigantea on castor oil-induced diarrhea model in rats showed remarkable anti-diarrheal effect.(1) Study evaluated the in vivo anti-diarrheal activity of ethanolic extract of C. gigantea root extract in wistar rats by castor oil-induced diarrhea, enteropooling and small intestinal transit models. Results showed dose dependent decrease in diarrhea at three doses of 100, 200, and 400 mg/kg in all three experimental models. Results suggest some prostaglandin inhibitory effect and an anti-motility effect. (37)
Latex / Wound Healing: Study using an excision and incision wound model showed to latex to have significant wound healing activity, similar to the standard FSC (Framycetin sulphate cream). (2) Study evaluated the wound healing potential of CG latex on excision wound induced model in rats. Topical application of 10% w/w latex ointment in petroleum gel for 14 days significantly improved wound contraction compared to control group of rats. The wound healing effect may be due to the high content of glycosides, flavonoids, phenolic compounds, and triterpenoids with antimicrobial and antioxidant properties. (31)
Antibacterial: Study showed the latex to possess potent bactericidal activity attributed to the presence of biologically active ingredients with antimicrobial activity of the ethanolic extract. (3)
Anti-Inflammatory: Anti-inflammatory studies of extracts of T procumbens and C gigantea showed greater anti-inflammatory action with the combined effect of CG and TP with ibuprofen than ibuprofen alone, probably through the potentiation of its inhibitory effect on the synthesis and release of various inflammatory mediators. (4) Study evaluated in-vitro anti-inflammatory activity of various extracts of leaves of C. gigantea. The ethanol extract of leaves showed significant inhibition using the albumin denaturation technique, with a degree of denaturation comparable to that produced by ibuprofen. (24)
Vasodilation: Effect of latex from C gigantea in the green frog R hexadactyla showed a significant increase in cardiac output. Evidence suggests the prime action of latex on the cardiovascular system involves changes in the cation (Ca, Na) permeability, with consequent excitation of Ca channels in the heart muscle and an increase coronary flow. Therefore, dilatation property is likely responsible for the pharmacologic actions of the latex. (5)
Hepatoprotective / Stem: Preliminary screening yielded triterpenoids, steroids, flavonoids and glycosides. Study showed C gigantea stem extract reduced lipid peroxidation and significantly improved biochemical parameters in CCL4-treated rats. (6)
Cytotoxic / Pregnanone: Study yielded a new pregnanone, named calotropone, together with a known glycoside, from the ethanolic extract of the roots of C gigantea. The compounds exhibited inhibitory effects toward chronic myelogenous leukemia K562 and human gastric cancer SGC-7901 cell lines. (7)
Antipyretic: Study showed the extract of C gigantea to have potent antipyretic activity against both yeast-induced and TAB-vaccine induced fever, suggesting a potential source for a cheaper and potent antipyretic agent. (8)
Insecticidal: Study evaluated methanol extract and soluble fractions of root bark of C. gigantea against several instar of larvae and adult Tribolium castaneum. The methanol extract showed lowest LD50 values against several instar of larvae and adult TC. No fumigant toxicity was found. (10)
Antimicrobial Activity / Cytotoxicity: Various extracts of leaves were evaluated for antimicrobial and cytotoxic activity. The n-hexane, carbon tetrachloride, chloroform, ethanol and water extracts showed antimicrobial activity against most of the test organisms. On Brine Shrimp Lethality Bioassay, the crude extract induced significant cytotoxic activity. (13)
Free Radical Scavenging Activity: Study evaluated the effects of chloroform extracts of leaf and flower on free radical scavenging activity and lipid profile in STZ-induced diabetic rats. Extracts caused a significant decrease in lipid peroxidation, SGPT, SGOT, alkaline phosphatase, and triglyceride levels. (14)
Hepatoprotective / Flowers: An ethanol extract of flowers showed antioxidant and hepatoprotective activity against carbon tetrachloride-induced liver damage in mice. The hepatoprotective activity was comparable to silymarin. (15)
Antihyperglycemic / Antinociceptive / Leaves: Study evaluated a methanol extract of leaves for antihyperglycemic and antinociceptive activity. Results showed significant dose-dependent reductions of blood glucose in oral glucose tolerance tests in glucose loaded mice. The extract also showed antinociceptive activity comparable to aspirin. (16)
Protease Inhibition / Modulation of PLA2 Activity / Leaves: Study showed Calotropis gigantea acts as protease inhibitors containing plant compounds, applicable as targets in molecular therapies. Both white and violet verities of Calotropis gigantea have also shown good PLA2 inhibition activity. (17)
Antibacterial Against Cariogenic Bacteria / Latex: Study evaluated the in vitro antibacterial potential of various extracts of C. gigantea against five cariogenic bacterial viz. Actinomyces viscosus, Lactobacillus acidophillus, L. casei, Streptococcus mitis, and S. mutans. The chloroform extracted fraction showed inhibitory effect against S. mutans and L. acidophilus. Study yielded a bioactive compound, methyl nonanoate, a saturated fatty acid. (19)
Active Metabolites / Antifungal: Study evaluated solvent extracts of leaves, flowers, and buds of C. gigantea for active metabolites against pathogenic fungi viz. Aspergillus niger, Rhizoctonia oryzae-sativae, Fusarium solani, and Trichoderma viride. Ethanol bud extracts showed highest growth reducing activity against F. solani, while aqueous bud extract showed growth reduction activity against R. oryzae-sativae. Results showed mixed results for the solvent extracts as antifungal drugs. (20)
Anhydrosophoradiol-3-acetate / Antitumor / Flower: Flower investigated the anti-tumor effect of anhydrosophoradiol-3-acetate (A3A), isolated from the flower of C. gigantea against Ehrlich's ascites carcinoma in Swiss albino mice. Results showed inhibition of EAC growth with improvement in cancer induced complications. (21)
Toxicity Studies: Study investigated acute and subacute toxicity of ethanolic extract of C. gigantea flower. Acute toxicity study at oral dose of 2000 mg/kg did not produce mortality or changes in behavior or gross appearance of internal organs of mice and rats. In subacute toxicity studies with various doses up to 1000 mg/k/d for 30 days, there were no signs of toxicity during the experimental period, with no changes in biochemical or hematologic parameters. Results suggest safety in single dose acute and repetitive subacute toxicity studies. (22)
Antifungal / Latex: Study evaluated the ethanolic extract of latex for in vitro activity against human pathogenic fungi. The extract yielded flavonoids, alkaloids, triterpenoids, steroids, saponins, phenols, and glycosides. The latex showed significant zone of inhibition in a dose dependent manner. (23)
Lupeol / Latex: Study isolated lupeol, a triterpenoid, from the latex of C. gigantea for the first time. Lupeol is a potent bioactive compound, which is vastly used as an anti-inflammatory compound. (24)
Anti-Asthma / Latex: Study evaluated the effect of a methanolic extract of root of C. gigantea on ovalbumin induced asthma and arachidonic acid induced paw edema in rats. Results showed anti-inflammatory, anti-lipoxygenase and antioxidant activity with therapeutic potential in the treatment of asthma. (25)
Anti-Diabetic / Flowers: Study evaluated the anti-diabetic activity of a chloroform extract of flowers in alloxan-induced hyperglycemia in vivo and inhibition of α-amylase and α-glucosidase in vitro. Results showed moderately significant anti-diabetic potential in reducing fasting glucose in the diabetic rats, and statistically significant maintenance of the serum marker antioxidant enzymes. The overall effect at 200 mg/kg was moderate as compared to standard drug glibenclamide. (26)
Antioxidant / Leaves: Study evaluated the in vitro antioxidant properties of hydroalcoholic extract of leaves against DPPH, reducing power assay, and NO scavenging activity. Results confirmed the antioxidant properties of the extract of leaves. Phenolic content was 63.08 ± 4.17 mg gallic acid equivalent per gram of extract. Total tannin was 0.52% expressed as tannic acid. Total flavonoid content was 46.97 46.97±1.95 µg/mL. (27)
Apoptosis / Human Hepatocellular Carcinoma / Roots: Study evaluated three root extracts of C. gigantea for antiproliferative activity on human hepatocellular carcinoma cells, HepG2, and human breast cancer cells, MCF-7. Results showed the methanolic root extract induced apoptosis of HepG2 cells by altering bax/bcl-2 expression. (28)
Anti-Arthritic / Leaves: Study evaluated the anti-arthritic activity of various extracts of leaves of C. gigantea in adjuvant induced arthritis model. The aqueous extract inhibited rat paw edema by 67.04% compared to diclofenac 68.29%, with significant suppression of leucocyte migration into the inflamed areas. Results suggest potential for anti-arthritic activity. (29)
Female Antifertility Effects: Study evaluated the antifertility and ovaro-uterotoxic activities of extracts of C. gigantea in animal models. Results showed the extracts were strongly antiestrogenic and antiprogestagenic. Although toxic at higher doses, the extract have the potential as female antifertility agents with proper control of toxicity. (30)
Silver Nanoparticles / Antibacterial Activity: Study reports on the green synthesis of silver nanoparticles from leaf extract of C. gigantea. In antibacterial testing, increasing concentrations of silver nanoparticles effectively reduced the number of colonies of V. alginolyticus isolated from wild Artemis franciscana cysts. (32)
Larvicidal, Repellent, and Ovicidal / Culex spp / Leaves: Study screened C. gigantea leaves for larvicidal, mosquito repellent and ovicidal activity against Culex gelidus and C. tritaeniorhynchus mosquitoes. Results suggest C. gigantea has potential as a natural source for a new, safe, and eco-friendly insecticide for control of CG and CT mosquitoes. (33)
Neuropharmacological Activity / Roots: A methanol extract and ethyl acetate fraction of C. gigantea roots exhibited statistically significant antianxiety, anticonvulsant, antidepressant, sedative, antistress and analgesic activities in experimental mice models. Flavonoids was the major class of phytoconstituents. (34)
Antivenom Activity: Study evaluated the antivenom activity of C. gigantea plant extract against Vipera russelii snake venom. Oral administration of CG plant extract at dose levels 200 and 400 mg/kbw effectively neutralized the lethal effect of 2LD50 and 3:D50 of V. russelii venom in in-vivo neutralization in mice. Plant extract at dose levels of 200 and 400 mg/kg showed significant anti-inflammatory activity at 240 min, an effect comparable with that produced by antivenom. (35)
CNS Activity / Toxicity Study / Leaves: Study evaluated the CNS activity of ethanolic extract of leaves of Calotropis gigantea. Results showed anticonvulsant, sedative, and muscle relaxant effect. Acute toxicity study showed safety of the extract up to a dose of 2000 mg/kg. (36)
Raw Material for Fiber-Reinforced Composite: Study evaluated the feasibility of applying two kinds of mudar fibers (seed fibers and bark fibers) as alternative raw material for fiber-reinforced composite. Findings suggest both types of fibers have the potential for replacing or supplementing other fibrous raw materials as reinforcing agent. (38)
Hepatoprotective / Root Bark: Study of suspensions of alcoholic extract of root bark of C. gigantea showed significant hepatoprotective activity in Wistar albino rats with hepatic injury induced by D-galactosamine. (39)

Tinctures in the cybermarket.

Godofredo U. Stuart Jr., M.D.

Last Update November 2015

IMAGE SOURCE / File:Calotropis gigantea Blanco2.258-original.png Flora de Filipinas / Franciso Manuel Blanco (OSA), 1880-1883 / Public Domain / Wikimedia Commons
OTHER IMAGE SOURCE / Calotropis gigantea close-up / File:Calotropis giganteaRHu5.JPG / Meneerke bloem / 20 Dec 2009 / GNU Free Documentation License / click on phto to see to source image/ Wikimedia Commons

Additional Sources and Suggested Readings
Studies on anti-diarrhoeal activity of calotropis gigantea r.br. in experimental animals / Havagiray R Chitme, Ramesh Chandra, Sadhna Kaushik / J Pharm Pharmaceut Sci (www.ualberta.ca/~csps) 7(1):70-75, 2004
WOUND HEALING ACTIVITY OF LATEX OF CALOTROPIS GIGANTEA / Narendra Nalwaya, Gaurav Pokharna et al / International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 1, Issue 1, July-Sep. 2009
Evaluation of Antibacterial Activity of Calotropis gigantea Latex Extract on Selected Pathogenic Bacteria / Sorimuthu Pillai Subramanian and Venkatesan Saratha / Journal of Pharmacy Research, Vol 3, No 3 (2010)
Evaluation of anti-inflammatory effect of Calotropis gigantea and Tridax procumbens on Wistar albino rats / Saumya Das, Sanjita Das et al /J. Pharm. Sci. & Res. Vol.1(4), 2009, 123-126.
Vasodilatation Effect of Latex from Calotropis gigantea in Green Frog Rana hexadactyla / B Sheelaa, S Mohamed Hussain et al / Asian Journal of Medical Sciences 2(1): 22-24, 2010
Hepatoprotective effects of Calotropis gigantea extract against carbon tetrachloride induced liver injury in rats / Gaurav Lodhi, Hemant Kumar Singh et al / Acta Pharm. 59 (2009) 89–96 /
A New Cytotoxic Pregnanone from Calotropis gigantea / Zhu-Nian Wang, Mao-Yuan Wang et al / Molecules 2008, 13, 3033-3039; DOI: 10.3390/molecules13123033
Evaluation of antipyretic activity of Calotropis gigantea (Asclepiadaceae) in experimental animals / H R Chitme, Ramesh Chandra, Sadhna Kaushik / Phytotherapy Research, Vol 19 Issue 5, Pages 454 - 456
Isolation of Stigmasterol and β-Sitosterol from Methanolic Extract of Root Bark of Calotropis gigantea (Linn) / M Rowshanul Habib et al / Pak. J. Biol. Sci., 10: 4174-4176 / DOI: 10.3923/pjbs.2007.4174.4176
Insecticidal Activity of Root Bark of Calotropis gigantea L. Against Tribolium castaneum (Herbst) / M Ashraful Alam, M Rowshanul Habib et al / World Journal of Zoology 4 (2): 90-95, 2009
Calotropis gigantea / Stephen H. Brown / University of Florida
Crown flower / Common names / Flowers of India
Antimicrobial Screening and Brine Shrimp Lethality Bioassay of Calotropis gigantea (Fam: Asclepiadaceae) / Sarder Fahim Hossain, Md. Siddiqul Islam, Salma Parvin, Tahiatul Shams, Mohammad Fahim Kadir, A. G. M. Mostofa, Muhammad Shahdaat Bin Sayeed* / J. Nat. Prod. Plant Resour., 2012, 2 (1):49-59

Free Radical Scavenging Activity of Calotropis gigantea on Streptozotocin-Induced Diabetic Rats / N. R. Rathod,* I. Raghuveer, H. R. Chitme, and R. Chandra / Indian J Pharm Sci. 2009 Nov-Dec; 71(6): 615–621. /
doi: 10.4103/0250-474X.59542
Hepatoprotective activity of Calotropis gigantea flowers against carbon-tetrachloride-induced liver damage in mice / Deepa Krushna Ingawale, / Satish Karbhari Mandlik, Ajay Digambar Kshirsagar / Journal of Complementary and Integrative, MedicineVolume 10, Issue 1 (Jul 2013)
Evaluation of antihyperglycemic and antinociceptive properties of leaves of Calotropis gigantea R.Br. / The Free Library
In Vitro Protease Inhibition, Modulation of PLA2 Activity and Protein Interaction Studies of Calotropis gigantea / DSVGK Kaladhar*, Govinda Rao Duddukuri, Ramesh K, Varahalarao Vadlapudi and Nagendra Sastry Yarla / J Clin Cell Immunol 2013, 4:5 / http://dx.doi.org/10.4172/2155-9899.1000165
Calotropis gigantea / Synonyms / The Plant List
Antibacterial and phytochemical studies on Calotropis gigantia (L.) R. Br. latex against selected cariogenic bacteria / Kalpesh B. Ishnava, Jenabhai B. Chauhan , Akanksha A. Garg, Arpit M. Thakkar / Saudi Journal of Biological Sciences
Volume 19, Issue 1, January 2012, Pages 87–91
Experimental Studies on Active Metabolites of Calotropis gigantea for Evaluation of Possible Antifungal Properties / Mandepudi David, Ravuru Bharath Kumar, Mandepudi Bhavani / International Research Journal of Pharmacy, 2013, 4(5)
Effect of anhydrosophoradiol-3-acetate of Calotropis gigantea (Linn.) flower as antitumoric agent against Ehrlich's ascites carcinoma in mice / Muhammad R. Habib, Muhammad R. Karim / Pharmacological Reports, 2013, 65, pp 761-767

Anti-inflammatory Activity of Calotropis gigantea Linn. Leaves Extract on In-vitro Models. / Jagtap V A*, Md Rageeb Md Usman, Salunkhe P S, Gagrani M B
/ International Journal of Current Pharmaceutical Review and Research
Volume 1, Issue 2, August - October 2010
Inhibitory effect of Calotropis gigantea extract on Ovalbumin-induced airway inflammation and Arachidonic acid induced inflammation in a murine model of asthma / Vipin Bulani*, Kailash Biyani, Ravindra Kale, Unmesh Joshi, Kishor Charhate, Dinesh Kumar, Ramesh Pagore / Int J Cur Bio Med Sci. 2011; 1(2): 19 – 25.
J. Anti-diabetic potential of chloroform extract of flowers of Calotropis gigantea: An in vitro and in vivo study / Choudhary N K, Jha A K, Sharma S, Goyal S, Dwivedi / Int J Green Pharm, Vol 5, No 4, pp 296-301.
In vitro antioxidant activity of Calotropis gigantea hydroalcohlic leaves extract / Namrata Singh*, Neetesh K Jain, Pushpendra Kannojia, Navneet Garud, Anupam K Pathak and Swaroop C Mehta / Der Pharmacia Lettre, 2010, 2(3): 95-100
Methanolic Root Extract of Calotropis gigantea Induces Apoptosis in Human Hepatocellular Carcinoma by Altering Bax/Bcl-2 Expression / Vishnu Priya, Prateek Jain, B. Meenashi Vanathi, P. Vasanth Raj, B. Venkatesh Kamath, J. Venkata Rao, N. Udupa, N. Sivagurunathan / American Journal of Pharmacological Sciences, 2015 3 (1), pp 13-17 /
DOI: 10.12691/ajps-3-1-3

Anti-arthritic activity of leaves of Calotropis gigantea Linn. / Kalpana S. Patil*, G. C. Mamatha, S. C. Chaturvedi / JOURNAL OF NATURAL REMEDIES
/ M. Mishra, R. K Gautam, R. Mathur* / Journal of Pharmaceutical Research And Opinion 1:3 (2011) 92 – 93
Evaluation of wound healing potential of Calotropis gigantea latex studied on excision wounds in experimental rats
/ V. Saratha, S. Subramanian , S. Sivakumar / Medicinal Chemistry Research, November 2010, Volume 19, Issue 8, pp 936-947
Green synthesis of Silver nanoparticles through Calotropis gigantea leaf extracts and evaluation of antibacterial activity against Vibrio alginolyticus / Vaseeharan Baskaralingam, Clara Gunapoorani Sargunar, Yong Chin Lin, Jiann Chu Chen
Larvicidal, repellent and ovicidal activity of Calotropis gigantea against Culex gelidus, Culex tritaeniorhynchus (Diptera: Culicidae) / Kumar, G., Karthik, L., K.V. Bhaskara Rao*, Kirthi, A.V., Rahuman, A.A. / Journal of Agricultural Technology 2012 Vol. 8(3): 869-880
Screening of Neuropharmacological Activities of Calotropis gigantea roots / Kawalpreet Kaur, Deepak Kumar, Suresh Kumar* / Journal of Pharmaceutical, Chemical and Biological Sciences, September-November 2014; 2(3): 186-196
EVALUATION OF ANTIVENOM ACTIVITY OF CALOTROPIS GIGANTEA PLANT EXTRACT AGAINST VIPERA RUSSELLI SNAKE VENOM / Nimmy Chacko*, Mohammed Ibrahim , Prerana Shetty and C.S. Shastry / International Journal of Pharmaceutical Sciences and Research. 2012;3(7)2272-2279
CNS activity of leaves extract of Calotropis gigantea / Santosh Dattatraya Ghule*, Gali Vidyasagar, Anil Bhandari, Praveen Sharma, Atul Parashuram Gunjal / Asian Pac J Trop Dis 2014; 4(Suppl 2): S902-S905
Evaluation of Calotropis gigantea Root in Experimental Diarrhea / Rumana Rahman, Fazlu Rehman, Shashank B, Rajashekar S, Gangadhar B, Chandrasekhar S, Sandeep V L V S / Int J. Pharm & Ind. Res, Vol 2, Issue 1, Jan-Mar 2012.
Evaluation of Calotropis gigantea as a Promising Raw Material for Fiber-reinforced Composite / Alireza Ashori, Zaker Bahreini / Journal of Composite Materials June 2009 vol. 43 no. 11 1297-1304 / DOI: 10.1177/0021998308104526
Hepatoprotective Activity of Calotropis gigantea Root Bark Experimental Liver Damage Induced by D-Galactosamine in Rats / *Pradeep Deshmukh, Tanaji Nandgude, Mahendra Singh Rathode, Anil Midha, Nitin Jaiswal / International Journal of Pharmaceutical Sciences and Nanotechnology, Volume 1, Issue 3, October - December 2008

It is not uncommon for links on studies/sources to change. Copying and pasting the information on the search window or using the DOI (if available) will often redirect to the new link page.

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