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Family Mimosoideae / Mimosaceae
Makahiya
Mimosa pudica Linn.
BASHFUL MIMOSA

Pa chou cao

Scientific names Other common names
Mimosa asperata Blanco Babain (Ilk.) 
Mimosa pudica Linn. Damohia (Tag.)
Han xiu cao (Chin.) Dilgansusu (Ilk.)
  Harupai (S. L. Bis.)
  Huya-huya (Bis.)
  Kiromkirom (S. L. Bis.)
  Makahia (Pang., Tag.)
  Sipug-sipug (Sub.) 
  Tuyag-huyag (P. Bis.)
  Torog-torog (Bik.)
  Bashful mimosa (Engl.)
  Humble plant (Engl.)
  Sensitive plant (Engl.)
  Shame plant (Engl.)
  Tickle-Me plant (Engl.)
  Pa chou cao (Chin.)
Makahia is a common name shared by Mimosa pudica (bashful mimosa) and Biophytum sensitivum (Damong bingkalat, little tree plant).

Other vernacular names
BENGALI : Laajak, Lajjavathi.
CHINESE : Pa chou cao, Zhi xiu cao, Hu he cao
DANISH : Almindelig mimose.
DUTCH : Kruidje-roer-me-niet.
FINNISH : Tuntokasvi.
FRENCH : Mimeuse commune, Mimeuse pudique, Sensitive.
GERMAN : Gemeine Mimose, Sinnpflanze.
HINDI : Chuimui, Lajaalu, Lajjavanthi, Lajouni.
ITALIAN / SWEDISH : Sensitiva.
SANSKRIT : Khadiraka, Lajjalu, Namaskaar, Namaskaari, Raktapaadi, Samangaa, Shamipatra.
SPANISH : Dormidera, Sensitiva, Vergonzosa.
TAMIL : Tottalavaadi.
TELUGU : Attaapatti.

Botany
Makahiya is a diffusely spreading, half-woody herb, with branched stems up to 1 meter long, sparingly prickly with numerous deflexed, bristly hairs. The leaves are very sensitive, both pinnae and leaflets, folding when touched. Pinnae are usually 4, digitately arranged at the end of each petiole, and 4 to 9 centimeters long. The leaflets are narrowly oblong, inequilateral, 1 to 1.5 centimeters long, sessile, sparingly bristly, with pointed tips. Heads are long-peduncled, solitary or 2 to 3 in each axil, about 1 centimeter in diameter. Pods are flat, slightly recurved, 1 to 2 centimeters long, with 3 to 5 one-sided joints that fall away on maturity. Florets are red in the upper part with pink to lavender filaments.

Distribution
- Common weed widely distributed in the Philippines in open, moist, waste places, open grasslands and open thickets, at low and medium altitudes in settled areas.
- Introduced from tropical America.
- Pantropic weed.

Constituents
- Seed contains a toxic alkaloid, mimosine, a non-protein alpha-amino acid, known to cause hair loss and depressed growth in mammals (an unlikely event in humans as this will require unusually large doses).
- Roots yield flavonoids, phytosterol, alkaloids, amino acids, tannins, glycoside, fatty acids.
- Leaf extract have yielded an adrenaline-like substance.
- Seeds contain a mucilage composed of d-xylose and d-glucoronic acid, yielding 17% greenish yellow fatty oil.
- Plant contains (1) tubulin with an ability to bind colchicene with its sulfhydryl groups. (2) crocetin dimethyl ester.

- Plant yields turgorine.
- Leaves and stems reported to contain the alkaloid mimosine; leaves yield mucilage; the roots yield tannins.

Properties
- Considered expectorant, antiasthmatic. analgesic, antispasmodic, alterant, sedative and antidepressant.
- Roots are bitter, astringent, acrid, alexipharmic, antispasmodic, aphrodisiac, constipating, cooling, diuretic, emetic, febrifuge, resolvent, vulnerary.
- Leaves are bitter, sudorific, tonic.
- Emetic effect attributed to mimosine.

Leaflet movement physiology
The leaflets fold together in the early evening and reopens at sunrise. It is called bashful or sensitive because the leaflets fold together on touching, warming and shaking. The phenomenon is called seismonastic movement due to a rapid change in turgor pressure and changes in membrane permeability in the pulvini cells in the leaf regions with rapid movement of calcium ions. At night, the leaves also fold and bend, termed nyctonastic movements (reaction to absence of light).
When the leaflets fold together on touching, they reopen in about 10 minutes.
• Seismonastic Movement / Actin Cystoskeleton: Study showed fragmentation of actin filaments occurring during bending was involved in the regulation of movement. The effect of phosphatase inhibitors on the actin cytoskeleton affects dynamic reorganization of actin filaments and causes the seismonastic movement.

Parts utilized
Entire plant.

Uses
Folkloric
- In the Philippines, roots used as diuretic; also used for dysentery and dysmenorrhea.
- Entire plant in decoction used as alterant and antiasthmatic.
- Root considered aphrodisiac, and used for bladder gravel and similar urinary complaints.
- Decoction or infusion of leaves used in asthma; expectorant.
- Used for hypertension, menorrhagia, glandular swelling, sore throat and hoarseness.
- Powdered seeds applied to wounds and sores.
- Bruised leaves applied to bruises.
- Decoction of leaves used for diabetes.
- Powdered roots and leaves taken with milk for piles and fistula.
- Juice applied externally to fistulous sores.
- Poultice of leaves for glandular swellings.
- Leaves and roots used for piles and fistula.
- Used as antifertility agent in some parts of India.
- 1:1 ethanol water extract used for pain relief.
- Seeds used a coffee substitute
- In China, used for treatment of anxiety and depression.
- In Ayurveda, used as antiasthmatic, aphrodisiac, analgesic and antidepressant; also used in diseases associated with corrupted bile and blood, bilious fever, piles, jaundice, leprosy, ulcers, and small pox.
- In India, used for birth control.
- In the Antiles, Guiana, and La Reunion, roots used vomitive.
- In Indo-China, seeds used as emetic.
- In Mexico, used to alleviate depression.
- In Punjab and Cashmere, seeds used for sore throat.
- In Concan, paste of leaves applied to hydrocoeles and glandular swellings.
- Infusion of leaves used for dysentery; also as bitter tonic.
- Roots used for leucoderma, vaginopathy, metropathy, ulcers, dysentery, inflammations, jaundice, asthma, small pox, strangury, fevers.
- Leaves used for hydrocoele, hemorrhoids, fistula, scrofula, conjunctivitis, wounds and hemorrhages.
- Whole plants used for bladder calculi; externally, for edema, rheumatism, myalgia and uterine tumors.
- Whole plant, crushed, used for itching and scabies.

Studies
• Antimicrobial: Study showed antimicrobial activity against Aspergillus fumigatus, Citrobacter divergens and Klebsiella pneumonia.
(6)
• Antimicrobial: Ethanolic extracts activity against B. subtilis, P. aeruginosa, K. pneumonia, A. flavus and T. rubrum. The antimicrobial activity was attributed to the presence of active constituents like alkaloids or tannins.
• Anticonvulsant: Study showed intraperitoneal use of Mimosa pudica decoction protected mice against pentylentetrazol and strychnine-induced seizures.
• Plant extracts showed the plant to be a moderate diuretic, depressed duodenal contractions (similar to atropine), promoted nerve regeneration and reduce menorrhagia.
• Also shown to have antidepressant activity.
• Antifertility Studies: Studies on the root extract of M. pudica showed antifertility effect with prolongation of the estrous cycle and disturbance of the secretion of gonadotropin hormones in albino mice.
(2)
• Antitoxin / Sea Snake Venom: A study in India screened several herbal plants for antivenin activity against common sea snake venom Enhydrina schistosa, the most toxic among the common sea snakes. The investigation showed antivenom activity in the alcoholic extract of Mimosa pudica, Mucuna pruriens, and Andrographis paniculata.
(3)
• Antitoxin: Study on the aqueous extract of dried roots of Mimosa pudica showed significant inhibitory effect on Naja naja and Bangarus caerulus venoms.
(9)
• Antitoxin / Venom Neutralizing: Of 17 plants screened, only M pudica showed 100% ability in neutralizing venom lethality. Study showed the potential use of M pudica as an antivenom agent of plant origin against five poisonous snake venoms found in Malaysia.
• Two new C-glycosylflavones from Mimosa pudica: Two new C-glycosylflavones were isolated from the whole plant of Mimosa pudica, and their structures were determined as 6,7,3?,4?-tetrahydroxyl-8-C-[?-l-rhamnopyranosyl-(1 ? 2)]-?-d-glucopyranosyl flavone (1), 5,7,3?,4?-tetrahydroxy-8-C[?-d-apiose-(1 ? 4)]-?-d-glycopyranosyl flavone (2).
(4)
• Chromoblastomycosis: Study isolated Fonsecaea from the thorns of M pudica and suggests it could be a natural source of infection for the fungus Fonsecaea pedrosoi.
• Seed Mucilage / Sustained-Release Excipient: Study showed the dissolution profile from formulation containing mucilage to drug in the proportion of 1:40 was found to be similar to the commercial sustained-release formulation of diclofenac.
Anti-Depressant: Study suggests that M pudica produces antidepressant effect in rats with a profile similar to two tricyclic antidepressants.
Anti-Malarial: Mimosine found to be an iron chelator
acting on malarial bugs by preventing the replication of cells.
Apoptotic: Mimosine also causes apoptosis and studied for treating ovarian cancer and other highly vascularized tumors.
Anthelmintic: The Anthelmintic effect of Makahiya (Mimosa pudica) leaves Extract in Native Chicken (Gallus domesticus) naturally infected with Gastro-intestinal Parasites (Thesis) (5)
Anti-Hepatotoxic / Antioxidant: Study showed the co-administration of Mimosa pudica aqueous extract significantly lowered the level of lipid peroxidation in alcohol-fed mice. (16)
Anti-Hyperglycemic: Mimosa pudica is one of eight medicinal plants in an Ayurvedic herbal formulation, Ilogen-Excel, showing antihyperglycemic effect in STZ-induced diabetic rats. (17)
Nerve-Regenerative: (1) Study showed Mimosa pudica extract possess nerve-regenerative potential in rats with sciatic nerve injury. (2) In rats with experimentally injured sciatic nerves, nerve regeneration was 30-40% higher in rats treated with M. pudica extract than the hydrocortisone treated group.
Antidiabetic Activity: In a study of alloxan-induced diabetic rats, the ethanolic extract of Mimosa pudica showed significant decrease of blood glucose level compared with Metformin as standard drug. (18)
Antioxidant / Antibacterial: Comparative antioxidant, antibacterial and general toxicity studies on extracts of two Bangladeshi medicinal plants, M pudica and M rubicau, showed both exhibited prominent antioxidant property. While M. rubicaulis did not show any antibacterial activity, M pudica displayed considerable bacteriostatic activity against all six bacterial strains tested - B cereus, B subtilis, E coli, ampicillin-resistant E coli, S aureus and P aeruginosa.
Antinociceptive / Toxicity Studies: In an acute toxicity study, a single dose of aqueous extract of 2000 mg KBW showed no clinical signs of toxicity or mortality. Study also showed dose-dependent central and peripheral analgesic property. (22)
Hypolipidemic: Chloroform extract exhibited significant hypolipidemic activity. Results suggest that biologically activity phytoconstituents such as flavonoids, glycosides alkaloids may be responsible for the activity. (23)
Tannins / Antivenom: Study showed tannins obtained from M. pudica was better than tannic acid in neutralizing the lethality of N. kaouthia venom in vitro. Results suggest M. pudica has a potential for treating N. Kaouthia snakebites. (25)
Wound Healing
: (1) Study of the methanolic extract exhibited good wound healing activity, an effect attributable to phenol constituents. (2) Study of shoot and root extracts showed good wound healing activity when compared to standard drug Gentamicin. (3) In an incision wound model, topical application of chloroform and methanolic root extracts showed wound-healing activity with a significant rise in breaking strength, dry weight, and hydroxyproline content of the granulation tissue. (12)(28)(29)
Hepatoprotective: Study evaluated the hepatoprotective effect of a methanolic extract of leaves of M. pudica in carbon tetrachloride induced liver damage in wistar albino rats. Results showed significant hepatoprotective effect with lowering of biochemical parameters and confirming histopathological changes. Results were comparable to standard hepatoprotective drug Silymarin. Effects may be due to active phytoconstituents flavonoids, glycosides, and alkaloids. (31)
Antiulcer: Evaluation in rats of extracts of M. pudica for anti-ulcer activity in ulcer models -- aspirin, alcohol, and pyloric ligation -- showed the alcoholic extract to significantly decrease the volume of gastric acid secretion, PH, free acidity and ulcer index. (32)
Homeophathic Mother Tinctures: Study showed significant differences in samples of mother tinctures. Alcohol content influenced the viscosity of tinctures.
Antioxidant Activity: Study evaluated the total flavonoid (TF) and total phenolic (TP) contents of ethanol extracts of whole plant, stem, leaf, and seed. Results showed the leaf extract with the highest amount of TF and TP, Results suggested Mp could be a potential rice source of natural antioxidants. (33)
Antioxidant: Study evaluated the in vitro antioxidant effect of an ethanolic extract of Mimosa pudica against free radical damage by different assay methods (DPPH, NO, ABTS, and H2O2). Results showed potent activity on Nitric Oxide and DPPH, compared to ascorbic acid and rutin as standards. (34)
Nootropic: Study evaluated nootropic effects in both acute and chronic models of amnesia induced by scopolamine and AlCl3. Results confirmed nootropic (cognition enhancement) activity of EEMP, attributed to flavonoids and its antioxidant property. (35)
Analgesic / Anti-Inflammatory: Study evaluated an ethanolic extract for analgesic and anti-inflammatory activity. Results showed potent antinociceptive action confirming the extract's central activity. In a carrageenin-induced paw edema model, results clearly demonstrated anti-inflammatory activity. (36)
Antitumor / Glycosylflavones: Six glycosylflavones isolated from Mimosa pudica were evaluated for antitumor activity. Results showed inhibition on the proliferation of three tumor cells studies, viz., MCF-7, JAR, and N-2 A. (37)
Cytotoxicity / Antioxidant: Various extracts of different plant parts (aerial parts and root) were screened for in vitro cytotoxicity, antioxidant, and antimicrobial activities. The methanolic crude extract of aerial parts showed moderate antioxidant activity. The petroleum ether and methanol crude extract showed potential cytotoxic activities by brine shrimp lethality assay. All crude extracts showed poor or no activity against test organisms. (38)

Availability
Wild-crafted.
Tinctures, seeds, extracts in the cybermarket.

Last Update November 2012

Photos © Godofredo Stuart / StuartXchange
OTHER IMAGE SOURCE / Seeds / Mimosa pudica L. - shameplant / Steve Hurst @ USDA-NRCS PLANTS Database / USDA
OTHER IMAGE SOURCE / Dataja:Mimosa pudica Blanco2.253-cropped.jpg / Public Domain / Flora de Filipinas / Franciso Manuel Blanco (OSA), 1880-1883 / Modifications by Carol Spears / Wikimedia Commons
SOURCES

Additional Sources and Suggested Readings
(1)
The Sensitive Plant - Mimosa Pudica
(2)
Effect of Mimosa pudica root extract on vaginal estrous and serum hormone for screening of antifertility activity in albino mice / M Ganguly et al / Contraception, Volume 76, Issue 6, Pages 482-485
(3)
Preliminary Screening of Herbal Plant Extracts for Anti-venom activity against Common Sea Snake (Enhydrina schistosa) Poisoning
(4)

Two new C-glycosylflavones from Mimosa pudica
(5)

The Anthelmintic effect of Makahiya (Mimosa pudica) leaves Extract in Native Chicken (Gallus domesticus)
naturally infected with Gastro-intestinal Parasites
/ Hadjula, Mukramel / Thesis
(6)
Phytochemical Screening and Antimicrobial Activity of the Plant Extracts of Mimosa pudica L. Against Selected Microbes / N Gandhiraja et al / Ethnobotanical Leaflets 13:618-24, 2009
(7)
Anticonvulsant activity of Mimosa pudica decoction / E Ngo Bum et al / Fitoterapia • Vol 75, Issues 3-4, June 2004, Pages 309-314 / doi:10.1016/j.fitote.2004.01.012
(8)

Effect of Lajjawanti (Mimosa Pudica) on Regeneration of Nerve / G.C. Prasad et al / Jur. Res. Ind. Med.10: 4, 1975 pp.37-44
(9)
Antitoxin activity of Mimosa pudica root extracts against Naja naja and Bangarus caerulus venoms
/ Subramani Meenatchisundara et al / Bangladesh J Pharmacol 2009; 4: 105-109
(10)
ISOLATION OF Fonsecaea pedrosoi FROM THORNS OF Mimosa pudica, A PROBABLE NATURALSOURCE OF CHROMOBLASTOMYCOSIS / Claudio Guedes SALGADO et al / Rev. Inst. Med. trop. S. Paulo46(1):33-36, January-February, 2004
(11)
Change in the Actin Cytoskeleton During Seismonastic Movement of Mimosa pudica / Nobuyuki Kanzawa et al / Plant and Cell Physiology, doi:10.1093/pcp/pcj022
(12)
Evaluation of wound healing activity of root of Mimosa pudica / Kokane D D et al / J Ethnopharmacol. 2009 Jul 15;124(2):311-5. Epub 2009 May 3
(13)
POTENTIAL OF MIMOSA PUDICA (MIMOSACEAE) AGAINST SNAKE ENVENOMATION / Vejayan J et al / Journal of Tropical Forest Science, Oct 2007
(14)
Evaluation of Mimosa pudica Seed Mucilage as Sustained-Release Excipient / Kuldeep Singh et al / AAPS PharmSciTech • DOI 10.1208/s12249-009-9307-1
(15)
Mimosa pudica may possess antidepressant actions in the rat / Molina Contreras et al / Phytomedicine. 1999 Nov;6(5):319-23

(16)
Antihepatotoxic and antioxidant defense potential of Mimosa pudica / Nazeema T.H. and Brindha V./ International Journal of Drug Discovery, ISSN: 0975–4423, Volume 1, Issue 2, 2009, pp-01-04
(17)
Antihyperglycaemic effect of 'Ilogen-Excel', an ayurvedic herbal formulation in streptozotocin-induced diabetes mellitus / S. Umamaheswari, P. S. Prince / Acta Pol Pharm, Vol. 64, No. 1. (b 2007), pp. 53-61.
(18)
ANTIDIABETIC ACTIVITY OF THE LEAVES OF MIMOSA PUDICA LINN IN ALBINO RATS / N G Sutar et al / Journal of Herbal Medicine and Toxicology 3 (1) 123-126 (2009)
(19)
PRELIMINARY PHARMACOGNOSTIC EVALUATIONS AND PHYTOCHEMICAL STUDIES ON ROOTS OF MIMOSA PUDICA (LAJVANTI) / Milind Pande, Anupam Pathak / International Journal of Pharmaceutical Sciences Review and Research, Volume 1, Issue 1, March – April 2010; Article 010
(20)

Comparative bioacitivtry studies on two Mimosa species / Samuel Genest, Conor Kerr, Ankit Shah et al / Bol. Latinoam. Caribe Plant. Med. Aromaticas Vol 7 (1) 2008.
(21)
Mimosa pudica / Sensitive Plant / Herbal Monograph / Himalaya Herbal Health Care
(22)
Antinociceptive Activity of Mimosa pudica Linn /
M Karthikeyan and M K Deepa / Iranian Journ of Pharma and Therapeutics, Jan 2010, Vol 9, No 1, 11-14
(23)
Hypolipidemic Activity of Chloroform Extract of Mimosa pudica Leaves / Rekha Rajendron and Ekambaram Krishnakumar / Avicenna Journal of Medical Biotechnology, Vol. 2, No. 4, October-December 2010
(24)
Phytochemical Screening and Antimicrobial Activity of the Plant Extracts of Mimosa pudica L. Against Selected Microbe / N Gandhiraja, S Sriram et al / Ethnobotanical Leaflets 13:618-24, 2009.
(25)
Efficacy of tannins from Mimosa pudica and tannic acid in neutralizing cobra (Naja kaouthia) venom / Sia FY, Vejayan J, Jamuna A, Ambu S / The Journal of Venomous Animals and Toxins including Tropical Diseases, 2011, Vol 17, No 1, Pp 42-48
(26)
Sorting Mimosa names / Maintained by: Michel H. Porcher, / MULTILINGUAL MULTISCRIPT PLANT NAME DATABASE
(27)
Mimosa pudica / Catalogue of Life, China
(28)
WOUND HEALING ACTIVITY OF MIMOSA PUDICA LINN FORMULATION / S.Kannan , S.Aravinth Vijay Jesuraj, Sam Jeeva Kumar, K.Saminathan et al /
International Journal of PharmTech Research, Vol.1, No.4, pp 1554-1558, Oct-Dec 2009
(29)
Wound healing evaluation of chloroform and methanolic extracts of mimosa pudica roots in rats
/ Jejo Paul, Saifulla Khan, Syed Mohammed, Basheeruddin Asdaq / Int J Biol Med Res. 2010; 1(4): 223-227
(30)
Phytochemical Analysis and Anti Microbial Activity of Mimosa pudica Linn. / Tamilarsi T and Ananthi T / Research Journal of Chemical Sciences, Vol. 2(2), 72-74, Feb. (2012
(31)
Hepatoprotective activity of Mimosa pudica leaves against Carbontetrachloride induced toxicity /
Rekha Rajendran, S. Hemalatha, K. Akasakalai, C.H. MadhuKrishna, Bavan Sohil, Vittal and R. Meenakshi Sundaram / Rekha Rajendran, et. al., /Journal of Natural Products, Vol. 2(2009):116-122
(32)/
Anti-ulcer activity of Mimosa pudica leaves against gastric ulcer in rats / G.Vinothapooshan and K.Sundar /
Research Journal of Pharmaceutical, Biological and Chemical Sciences, 1(4), October – December 2010
(33)
Studies on the active components and antioxidant activities of the extracts of Mimosa pudica Linn. from southern China / Jing Zhang, Ke Yuan, Wen-long Zhou, Jian Zhou, Ping Yang / Phcog Mag 2011;7:35-9
(34)
In Vitro Antioxidant Evaluation of Mimosa pudica / P. Muthukumaran*, P. Shanmuganathan and C. Malathi / Asian J. Pharm. Res. 2011; Vol. 1: Issue 2, Pg 44-46
(35)
Nootropic Studies of Ethanolic Extract of Mimosa pudica Linn. in Albino Wistar Rats / Sibi P Ittiyavirah & Delphia P George / American Journal of Phytomedicine and Clinical Therapeutics
(36)
EVALUATION OF ANALGESIC AND ANTI-INFLAMMATORY POTENTIAL OF MIMOSA PUDICA LI NN
/
PRADEEP KUMAR VIKRAM*, REETESH MALVI, DEEPAK KUMAR JAIN / Int J Curr Pharm Res, Vol 4, Issue 4, 47-50
(37)
Studies on antitumor activities of six glycosylflavones from Mimosa pudica / Jian-xin Zhu ; Huai-xia Yang ; Ke Yuan / Yu-xian Li ; Coll. of Pharmacy, Henan Univ. of Traditional Chinese Med., Zhengzhou, China
(38)
Cytotoxicity, Antimicrobial and Antioxidant Studies of the Different Plant Parts of Mimosa Pudica / Sadia Afreen Chowdhury, Jannatul Islam, Md Mahfujur Rahaman, Md Mostafizur Rahman, Nowshin Nowaz Rumzhum, Rebeka Sultana, Most. Nazma Parvin / S. J. Pharm. Sci.1(1&2): 80-84 / doi:10.3329/sjps.v1i1.1813

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