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Family Rubiaceae
Suliak-daga
Canthium horridum Blume

Zhu du le

Scientific names Common names
Canthium horridum Blume Anonot-ti-babui (Pang.) 
Canthium hebecladum  Blanco Barsik (Ilk.) 
Canthium parviflorum Bartl. Dayap-dayap (Bik.) 
Canthium pauciflorum Blanco Kuliak-daga (Tag.) 
Plectronia horrida (Blume) Benth & Hook. f. Mimisam (Ilk.) 
  Suliak-daga (Tag.) 
  Zhu du mu (Chin.)
Some compilations list Canthium dicocum and Canthium horridum as synonyms. Quisumbing's compilation list the species separately: (1) Canthium dicocum (Gaertn) Merr., malakape, and (2) Canthium horridum Blume, kuliak-daga.

Botany
Kuliak-daga is a shrub or a small tree growing up to 2 to 5 meters. Branches are somewhat hairy and armed with sharp, slender axillary spines 5 to 10 millimeters in length. Leaves are ovate to elliptic-ovate, 1 to 2.5 centimeters long, short-petioled, and pointed at both ends. Flowers are greenish-yellow or nearly white, about 6 millimeters long, borne singly in the axils of the leaves. Fruit is red, fleshy, ovoid, about 7 millimeters long.

Distribution
- Found in dry thickets at low altitudes in Pangasinan, Zambales, Bulacan, Rizal, Camarines, and Sorsogon Provinces in Luzon.
- Also occurs in Burma to Malaya.

Parts used
Leaves and bark.

Constituents
• Phytochemical study showed the roots to predominantly consist of triterpenes, alkaloids, anthraquinones, steroids, organic acid, phenols and carbohydrates.
• Study of essential oils from CH showed the main components to be 1,2-benzenedicarboxylic acid bis(2-methylpropyl) ester(36.08%),bis(2-ethylhexyl) phthalate(13.82%),n-hexadecanoic acid(8.32%),(Z,Z,Z)-9,12,15octadecatrien-1-ol(9.61%) among others.

Uses
Edibility
· In Java, confections are made from the acid fruit.
Folkloric
· In the Philippines, boiled leaves and bark used to hasten menstruation.
· In Malaya, plant is used for wounds and fevers.
· In Indo-China, bark and young twigs used for dysentery.
· Decoction also used after childbirth.
• In China, leaves are mashed and used externally for snakebites and plaster from mashed leaves used for foot pains.

• Boiled fruits used to treat foot wounds.

Studies
Anti-Bacterial: Study isolated compounds found for the first time, Carulignan, lupeol, b-sitosterol, among many others. The chloroform fraction showed anti-bacterial activities.
Phytochemicals / Antibacterial:
Study of the chemical composition of the roots of C horridum yielded triterpene, alkaloid, anthraquinone, steroid, organic acid, phenol, carbohydrates among others. The chloroform fraction was shown to have antibacterial properties.
Constituents / Antimicrobial:
Study of CH stems yielded ten compounds: syringaresinol, scoparone, scopoletin, 3'-methoxy-4'-hydroxy-trans-cinnamaldehyde, sinapic aldehyde, syringic acid, mannitol, vanillic acid 4-O-beta-D-glucopyranoside, beta-daucosterol and beta-sitosterol. Siringic acid had the highest activity against Bacillus subtilis; syringaresinol showed good activity against E coli, B subtilis and S aureus.
Phenolics / Antioxidant:
Study of leaves showed the polyphenol content of 0.4879%. Results show the leaves had strong antioxidant activity, with an IC50 value of 0.35mg/mL.


Availability
Wild-crafted.

Last Update August 2012

Photos © Godofredo Stuart / StuartXchange
IMAGE SOURCE: Public Domain / File:Canthium horridum Blanco1.57-original.png / Flora de Filipinas / Francisco Manuel Blanco (O.S.A) / 1880 - 1883 / Wikimedia Commons

Additional Sources and Suggested Readings
(1)
GC-MS Analysis of Essential Oils from the Leaves of Canthium horridum / Chen Guang-ying, Luo Xiao-xue et al / DOI: CNKI:SUN:HBDD.0.2007-05-011
(2)
Studies on Chemical Constituents of Canthium Simile Merr. and Canthium Horridum Bl. and Their Antibiotics Activities /
(3)
Chemical constituents and antimicrobial activities of Canthium horridum / Yang B, Chen G et al / Nat Prod Commun. 2010 Jun;5(6):913-4.
(4)
Canthium horridum Blume / Catalogue of Life, China, 2010
(5)
Study on determination of total polyphenolic content and antioxidant activity of the leaves from Canthium horridum Bl. / SONG Xin-ming, CHEN Guang-ying,YIN Wen-qing,WANG An-wei, ZHANG Yong-qiang, XIE Dong-xia / Science and Technology of Food Industry, 2009-06


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